A TB-HIV/AIDS coinfection model and optimal control treatment
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Publication:255869
DOI10.3934/DCDS.2015.35.4639zbMATH Open1365.92134arXiv1501.03322OpenAlexW2092837422WikidataQ57650600 ScholiaQ57650600MaRDI QIDQ255869FDOQ255869
Authors: Delfim F. M. Torres, Cristiana J. Silva 
Publication date: 9 March 2016
Published in: Discrete and Continuous Dynamical Systems (Search for Journal in Brave)
Abstract: We propose a population model for TB-HIV/AIDS coinfection transmission dynamics, which considers antiretroviral therapy for HIV infection and treatments for latent and active tuberculosis. The HIV-only and TB-only sub-models are analyzed separately, as well as the TB-HIV/AIDS full model. The respective basic reproduction numbers are computed, equilibria and stability are studied. Optimal control theory is applied to the TB-HIV/AIDS model and optimal treatment strategies for co-infected individuals with HIV and TB are derived. Numerical simulations to the optimal control problem show that non intuitive measures can lead to the reduction of the number of individuals with active TB and AIDS.
Full work available at URL: https://arxiv.org/abs/1501.03322
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Epidemiology (92D30) Structural stability and analogous concepts of solutions to ordinary differential equations (34D30) Applications of optimal control and differential games (49N90)
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