Cost-effectiveness analysis of optimal control measures for tuberculosis
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Publication:486630
DOI10.1007/S11538-014-0028-6zbMATH Open1330.92133arXiv1409.3496OpenAlexW3102842140WikidataQ41729889 ScholiaQ41729889MaRDI QIDQ486630FDOQ486630
Authors: Paula Rodrigues, Cristiana J. Silva, Delfim F. M. Torres 
Publication date: 16 January 2015
Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)
Abstract: We propose and analyse an optimal control problem where the control system is a mathematical model for tuberculosis that considers reinfection. The control functions represent the fraction of early latent and persistent latent individuals that are treated. Our aim is to study how these control measures should be implemented, for a certain time period, in order to reduce the number of active infected individuals, while minimizing the interventions implementation costs. The optimal intervention is compared along different epidemiological scenarios, by varying the transmission coefficient. The impact of variation of the risk of reinfection, as a result of acquired immunity to a previous infection for treated individuals on the optimal controls and associated solutions, is analysed. A cost-effectiveness analysis is done, to compare the application of each one of the control measures, separately or in combination.
Full work available at URL: https://arxiv.org/abs/1409.3496
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