Multiobjective optimization to a TB-HIV/AIDS coinfection optimal control problem
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Publication:725841
DOI10.1007/S40314-017-0438-9zbMATH Open1433.92050arXiv1703.05458OpenAlexW3100208527WikidataQ57650340 ScholiaQ57650340MaRDI QIDQ725841FDOQ725841
Cristiana J. Silva, Roman Denysiuk, Delfim F. M. Torres
Publication date: 2 August 2018
Published in: Computational and Applied Mathematics (Search for Journal in Brave)
Abstract: We consider a recent coinfection model for Tuberculosis (TB), Human Immunodeficiency Virus (HIV) infection and Acquired Immunodeficiency Syndrome (AIDS) proposed in [Discrete Contin. Dyn. Syst. 35 (2015), no. 9, 4639--4663]. We introduce and analyze a multiobjective formulation of an optimal control problem, where the two conflicting objectives are: minimization of the number of HIV infected individuals with AIDS clinical symptoms and coinfected with AIDS and active TB; and costs related to prevention and treatment of HIV and/or TB measures. The proposed approach eliminates some limitations of previous works. The results of the numerical study provide comprehensive insights about the optimal treatment policies and the population dynamics resulting from their implementation. Some nonintuitive conclusions are drawn. Overall, the simulation results demonstrate the usefulness and validity of the proposed approach.
Full work available at URL: https://arxiv.org/abs/1703.05458
Epidemiology (92D30) Multi-objective and goal programming (90C29) Applications of optimal control and differential games (49N90)
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Cited In (11)
- Nonlinear adaptive control of tuberculosis with consideration of the risk of endogenous reactivation and exogenous reinfection
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- A fractional-order delay differential model with optimal control for cancer treatment based on synergy between anti-angiogenic and immune cell therapies
- Optimal control for cancer treatment mathematical model using Atangana-Baleanu-Caputo fractional derivative
- Optimal control of variable-order fractional model for delay cancer treatments
- Optimal control of a heroin epidemic mathematical model
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