Analysis and optimal control of an intracellular delayed HIV model with CTL immune response

DOI10.1007/S11786-018-0333-9zbMATH Open1403.34057arXiv1801.10048OpenAlexW3101203435WikidataQ57650330 ScholiaQ57650330MaRDI QIDQ1993370FDOQ1993370

Karam Allali, Sanaa Harroudi, Delfim F. M. Torres

Publication date: 5 November 2018

Published in: Mathematics in Computer Science (Search for Journal in Brave)

Abstract: A delayed model describing the dynamics of HIV (Human Immunodeficiency Virus) with CTL (Cytotoxic T Lymphocytes) immune response is investigated. The model includes four nonlinear differential equations describing the evolution of uninfected, infected, free HIV viruses, and CTL immune response cells. It includes also intracellular delay and two treatments (two controls). While the aim of first treatment consists to block the viral proliferation, the role of the second is to prevent new infections. Firstly, we prove the well-posedness of the problem by establishing some positivity and boundedness results. Next, we give some conditions that insure the local asymptotic stability of the endemic and disease-free equilibria. Finally, an optimal control problem, associated with the intracellular delayed HIV model with CTL immune response, is posed and investigated. The problem is shown to have an unique solution, which is characterized via Pontryagin's minimum principle for problems with delays. Numerical simulations are performed, confirming stability of the disease-free and endemic equilibria and illustrating the effectiveness of the two incorporated treatments via optimal control.

Full work available at URL: https://arxiv.org/abs/1801.10048

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zbMATH Keywords

stabilityoptimal controltreatmentHIV modelingintracellular time delay

Mathematics Subject Classification ID

Medical epidemiology (92C60) Stability theory of functional-differential equations (34K20) Asymptotic theory of functional-differential equations (34K25) Qualitative investigation and simulation of models involving functional-differential equations (34K60) Optimality conditions for problems involving ordinary differential equations (49K15)

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Cited In (14)

• Dynamical behaviors and optimal control problem of an \textit{SEIRS} epidemic model with interventions
• Stability analysis of a delayed HIV-TB co-infection model in resource limitation settings
• Optimal control of an HIV model with a trilinear antibody growth function
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• Optimal control in a multi-pathways HIV-1 infection model: a comparison between mono-drug and multi-drug therapies
• Mathematical Analysis of the Dynamics of HIV Infection with CTL Immune Response and Cure Rate
• Stability and Hopf bifurcation in a virus model with self-proliferation and delayed activation of immune cells
• Hopf bifurcation in a CTL-inclusive HIV-1 infection model with two time delays
• Global dynamics of a delayed diffusive virus infection model with cell-mediated immunity and cell-to-cell transmission
• Optimal control of viral infection model with saturated infection rate
• Discrete-Time System of an Intracellular Delayed HIV Model with CTL Immune Response
• Optimal control of an HIV model with CTL cells and latently infected cells
• Pest control using farming awareness: impact of time delays and optimal use of biopesticides
• Global properties of a virus dynamics model with self-proliferation of CTLs

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