Optimal control of an HIV model with a trilinear antibody growth function

DOI10.3934/DCDSS.2021148MaRDI QIDQ2118450zbMATH OpenOpenAlexFDO

Authors Karam Allali, Sanaa Harroudi, Delfim F. M. Torres

Publication date 22 March 2022

Published in Discrete and Continuous Dynamical Systems. Series S (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2105.10291

zbMATH Keywords

stabilityoptimal controltreatmentadaptive immune responseHIV modeling

Mathematics Subject Classification ID

Epidemiology (92D30) Existence theories for optimal control problems involving ordinary differential equations (49J15) Optimality conditions for problems involving ordinary differential equations (49K15)

Abstract: We propose and study a new mathematical model of the human immunodeficiency virus (HIV). The main novelty is to consider that the antibody growth depends not only on the virus and on the antibodies concentration but also on the uninfected cells concentration. The model consists of five nonlinear differential equations describing the evolution of the uninfected cells, the infected ones, the free viruses, and the adaptive immunity. The adaptive immune response is represented by the cytotoxic T-lymphocytes (CTL) cells and the antibodies with the growth function supposed to be trilinear. The model includes two kinds of treatments. The objective of the first one is to reduce the number of infected cells, while the aim of the second is to block free viruses. Firstly, the positivity and the boundedness of solutions are established. After that, the local stability of the disease free steady state and the infection steady states are characterized. Next, an optimal control problem is posed and investigated. Finally, numerical simulations are performed in order to show the behavior of solutions and the effectiveness of the two incorporated treatments via an efficient optimal control strategy.

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Cited in

(2)

• Optimal control of an HIV infection model with logistic growth, celluar and homural immune response, cure rate and cell-to-cell spread
• Analysis and optimal control of an HIV model with logistic growth and infected cells in eclipse phase

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