Optimal control of an HIV model with a trilinear antibody growth function

DOI10.3934/DCDSS.2021148zbMATH Open1486.92197arXiv2105.10291OpenAlexW3215194196MaRDI QIDQ2118450FDOQ2118450

Karam Allali, Delfim F. M. Torres, Sanaa Harroudi

Publication date: 22 March 2022

Published in: Discrete and Continuous Dynamical Systems. Series S (Search for Journal in Brave)

Abstract: We propose and study a new mathematical model of the human immunodeficiency virus (HIV). The main novelty is to consider that the antibody growth depends not only on the virus and on the antibodies concentration but also on the uninfected cells concentration. The model consists of five nonlinear differential equations describing the evolution of the uninfected cells, the infected ones, the free viruses, and the adaptive immunity. The adaptive immune response is represented by the cytotoxic T-lymphocytes (CTL) cells and the antibodies with the growth function supposed to be trilinear. The model includes two kinds of treatments. The objective of the first one is to reduce the number of infected cells, while the aim of the second is to block free viruses. Firstly, the positivity and the boundedness of solutions are established. After that, the local stability of the disease free steady state and the infection steady states are characterized. Next, an optimal control problem is posed and investigated. Finally, numerical simulations are performed in order to show the behavior of solutions and the effectiveness of the two incorporated treatments via an efficient optimal control strategy.

Full work available at URL: https://arxiv.org/abs/2105.10291

zbMATH Keywords

stabilityoptimal controltreatmentadaptive immune responseHIV modeling

Mathematics Subject Classification ID

Epidemiology (92D30) Existence theories for optimal control problems involving ordinary differential equations (49J15) Optimality conditions for problems involving ordinary differential equations (49K15)

Cites Work

• Title not available (Why is that?)
• Title not available (Why is that?)
• A TB-HIV/AIDS coinfection model and optimal control treatment
• Mathematical Analysis of HIV-1 Dynamics in Vivo
• A model of HIV-1 infection with two time delays: mathematical analysis and comparison with patient data
• Dynamics of a HIV-1 infection model with cell-mediated immune response and intracellular delay
• Differential equations. Classical to controlled
• Quantifying T lymphocyte turnover
• Killer cell dynamics. Mathematical and computational approaches to immunology.
• Optimal HIV treatment by maximising immune response
• Estimating kinetic parameters from HIV primary infection data through the eyes of three different mathematical models
• Mathematical biology of HIV infections: Antigenic variation and diversity threshold
• Viral dynamics model with CTL immune response incorporating antiretroviral therapy
• Optimal control of a delayed HIV model
• Global Stability for a HIV/AIDS Model
• Multiobjective optimization to a TB-HIV/AIDS coinfection optimal control problem
• Analysis and optimal control of an intracellular delayed HIV model with CTL immune response
• Modeling and optimal control of HIV/AIDS prevention through PrEP
• Table errata: Table of integrals, series, and products [corrected and enlarged edition, Academic Press, New York, 1980; MR 81g:33001] by I. S. Gradshteyn [I. S. Gradshteĭn] and I. M. Ryzhik
• Stability and optimal control of a delayed HIV model
• Modelling and optimal control of HIV/AIDS prevention through PrEP and limited treatment
• The spread of a financial virus through Europe and beyond
• A stochastic SICA epidemic model for HIV transmission
• A bare-bones mathematical model of radicalization
• Modeling TB-HIV syndemic and treatment
• On HIV Model with Adaptive Immune Response, Two Saturated Rates and Therapy

Cited In (1)

• Optimal control of an HIV infection model with logistic growth, celluar and homural immune response, cure rate and cell-to-cell spread

This page was built for publication: Optimal control of an HIV model with a trilinear antibody growth function

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2118450)