A mixed-culture model of a probiotic biofilm control system
Summary: We present a mathematical model and computer simulations for the control of a pathogenic biofilm by a probiotic biofilm. This is a substantial extension of a previous model of control of a pathogenic biofilm by microbial control agents that are suspended in the aqueous bulk phase [\textit{H. Khassehkhan} and \textit{H. J. Eberl}, ibid. 9, No.~1, 47--67 (2008; Zbl 1145.92002)]. The mathematical model is a system of double-degenerate diffusion-reaction equations for the microbial biomass fractions probiotics, pathogens and inert bacteria, coupled with convection-diffusion-reaction equations for two growth controlling substrates, protonated lactic acids and hydrogen ions (pH). The latter are produced by the bacteria and become detrimental at high concentrations. In simulation studies, we find that the site of attachment of probiotics in the flow channel is crucial for success and efficacy of the probiotic control mechanism.
- A mixed-culture biofilm model with cross-diffusion
- Modeling and simulation of a bacterial biofilm that is controlled by pH and protonated lactic acids
- Hybrid model of bacterial biofilm growth
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- Modeling of biocide action against biofilm
- A multidimensional multispecies continuum model for heterogeneous biofilm development
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- A model of optimal dosing of antibiotic treatment in biofilm
- Antagonistic control of microbial pathogens under iron limitations by siderophore producing bacteria in a chemostat setup
- Continuum and discrete approach in modeling biofilm development and structure: a review
- An efficient implicit spectral element method for time-dependent nonlinear diffusion equations by evaluating integrals at one quadrature point
- Discrete attachment to a cellulolytic biofilm modeled by an Itô stochastic differential equation
- Predicting stability of mixed microbial cultures from single species experiments. I: Phenomenological model
- Predicting stability of mixed microbial cultures from single species experiments. II: Physiological model
- Probiotics as cheater cells: parameter space clustering for individualized prescription
- Analysis of Adaptive Response to Dosing Protocols for Biofilm Control
- Model parameter uncertainties in a dual-species biofilm competition model affect ecological output parameters much stronger than morphological ones
- Exploring aeration strategies for enhanced simultaneous nitrification and denitrification in membrane aerated bioreactors: a computational approach
- Modeling nitrogen removal in membrane aerated biofilm reactors: the role of nitritation, denitritation, and anammox nitrogen removal
- A mixed-culture biofilm model with cross-diffusion
- Modeling and simulation of a bacterial biofilm that is controlled by pH and protonated lactic acids
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