The HPV vaccination strategy: could male vaccination have a significant impact?

DOI10.1080/17486700903486613MaRDI QIDQ612808zbMATH OpenOpenAlexDBLPWikidataFDO

Authors V. L. Brown, K. A. Jane White

Publication date 30 December 2010

Published in Computational \& Mathematical Methods in Medicine (Search for Journal in Brave)

Full work available at URL https://eudml.org/doc/226991

Mathematics Subject Classification ID

Probabilistic models, generic numerical methods in probability and statistics (65C20) Medical applications (general) (92C50) Medical epidemiology (92C60)

Review text

Summary: We investigate the potential success of the human papilloma virus (HPV) vaccine, taking into consideration possible waning immunity and the influence of behavioural parameters. We use a compartmental, population-level ordinary differential equation (ODE) model. We find the effective reproductive value for HPV, \(R_{0}^{e}\), which measures the threshold for infection outbreak in a population that is not entirely susceptible, together with infection prevalence. We study the effects of different parameters on both of these quantities. The results show that the waning immunity plays a large part in allowing infection to persist. The proportion of the population not sexually active when vaccination occurs affects \(R_{0}^{e}\), as does the rate at which individuals become sexually active. In several cases, infection persists as a result of an infection reservoir in the male cohort. To explore this further, we introduce male vaccination and find the conditions for which vaccination of males could be considered appropriate.

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(13)

• A two-sex model of human papillomavirus infection: vaccination strategies and a case study
• The impact of vaccination on human papillomavirus infection with disassortative geographical mixing: a two-patch modeling study
• A model to assess the effect of vaccine compliance on human papillomavirus infection and cervical cancer
• Cost-effectiveness evaluation of gender-based vaccination programs against sexually transmitted infections
• The dynamics of HPV infection and cervical cancer cells
• A dynamic model to assess human papillomavirus vaccination strategies in a heterosexual population combined with men who have sex with men
• Optimal control with multiple human papillomavirus vaccines
• Impact of prophylactic vaccination against human papillomavirus infection
• The impact of vaccination to control human papillomavirus dynamics
• Uncertainty and sensitivity of the sexual behavior changes to the current human papillomavirus vaccination campaign in Spain
• Mathematics + cancer: an undergraduate ``bridge course in applied mathematics
• Qualitative study of the role of Pap screening on HPV transmission dynamics
• From primary HPV infection to carcinoma in situ: a mathematical approach to cervical intraepithelial neoplasia

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