Structure learning for zero-inflated counts with an application to single-cell RNA sequencing data

DOI10.1214/23-AOAS1732arXiv2011.12044OpenAlexW3110219854MaRDI QIDQ6138580FDOQ6138580

Thi Kim Hue Nguyen, Davide Risso, Monica Chiogna, Author name not available (Why is that?)

Publication date: 16 January 2024

Published in: The Annals of Applied Statistics (Search for Journal in Brave)

Abstract: The problem of estimating the structure of a graph from observed data is of growing interest in the context of high-throughput genomic data, and single-cell RNA sequencing in particular. These, however, are challenging applications, since the data consist of high-dimensional counts with high variance and over-abundance of zeros. Here, we present a general framework for learning the structure of a graph from single-cell RNA-seq data, based on the zero-inflated negative binomial distribution. We demonstrate with simulations that our approach is able to retrieve the structure of a graph in a variety of settings and we show the utility of the approach on real data.

Full work available at URL: https://arxiv.org/abs/2011.12044

zbMATH Keywords

graphical modelsstructure learningzero-inflated countssingle-cell RNA-seq

Mathematics Subject Classification ID

Applications of statistics (62Pxx)

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Cited In (1)

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