Modeling identifies variability in SARS-CoV-2 uptake and eclipse phase by infected cells as principal drivers of extreme variability in nasal viral load in the 48 h post infection

DOI10.1016/J.JTBI.2023.111470MaRDI QIDQ6174208zbMATH OpenFDO

Authors Jason Pearson, Timothy Wessler, Alex W. J. Chen, Richard C. Boucher, Ronit Freeman, S. K. Lai, Raymond Pickles, M. Gregory Forest

Publication date 14 July 2023

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/J.JTBI.2023.111470

zbMATH Keywords

mechanistic modelingnasal infectionSARS-CoV-2viral load

Mathematics Subject Classification ID

Pathology, pathophysiology (92C32)

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Cites work

• A hybrid discrete-continuum model of immune responses to SARS-CoV-2 infection in the lung alveolar region, with a focus on interferon induced innate response

Cited in

(1)

• An analytical, numerical and experimental study of in-vitro SARS-CoV-2 evolution in Vero B4 cells

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