Identifiability of Chemical Reaction Networks with Intrinsic and Extrinsic Noise from Stationary Distributions
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Publication:6174682
Abstract: Many biological systems can be modeled as a chemical reaction network with unknown parameters. Data available to identify these parameters are often in the form of a stationary distribution, such as that obtained from measurements of a cell population. In this work, we introduce a framework for analyzing the identifiability of the reaction rate coefficients of chemical reaction networks from stationary distribution data. Working with the linear noise approximation, which is a diffusive approximation to the chemical master equation, we give a computational procedure to certify global identifiability based on Hilbert's Nullstellensatz. We present a variety of examples that show the applicability of our method to chemical reaction networks of interest in systems and synthetic biology, including discrimination between possible molecular mechanisms for the interaction between biochemical species.
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Cited in
(10)- An inverse problem in reaction kinetics
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- Identifiability of stochastically modelled reaction networks
- Learning chemical reaction networks from trajectory data
- Identifiability from a few species for a class of biochemical reaction networks
- Parameter estimation for models of chemical reaction networks from experimental data of reaction rates
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