Different strategies for cancer treatment: mathematical modelling
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Publication:634423
DOI10.1080/17486700802536054zbMATH Open1317.92037arXivq-bio/0605046OpenAlexW2120669479MaRDI QIDQ634423FDOQ634423
Authors: O. G. Isaeva, Vladimir Osipov 
Publication date: 2 August 2011
Published in: Computational \& Mathematical Methods in Medicine (Search for Journal in Brave)
Abstract: We formulate and analyze a mathematical model describing immune response to avascular tumor under the influence of immunotherapy and chemotherapy and their combinations as well as vaccine treatments. The effect of vaccine therapy is considered as a parametric perturbation of the model. In the case of a weak immune response, neither immunotherapy nor chemotherapy is found to cause tumor regression to a small size, which would be below the clinically detectable threshold. Numerical simulations show that the efficiency of vaccine therapy depends on both the tumor size and the condition of immune system as well as on the response of the organism to vaccination. In particular, we found that vaccine therapy becomes more effective when used without time delay from a prescribed date of vaccination after surgery and is ineffective without preliminary treatment. For a strong immune response, our model predicts the tumor remission under vaccine therapy. Our study of successive chemo/immuno, immuno/chemo and concurrent chemoimmunotherapy shows that the chemo/immuno sequence is more effective while concurrent chemoimmunotherapy is more sparing.
Full work available at URL: https://arxiv.org/abs/q-bio/0605046
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- A novel method for simulating the extracellular matrix in models of tumour growth
- On a multiobjective optimal control of a tumor growth model with immune response and drug therapies
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