Different strategies for cancer treatment: mathematical modelling

DOI10.1080/17486700802536054zbMATH Open1317.92037OpenAlexW2120669479MaRDI QIDQ634423FDOQ634423

Authors O. G. Isaeva, Vladimir Osipov

Publication date 2 August 2011

Published in Computational \& Mathematical Methods in Medicine (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/q-bio/0605046

zbMATH Keywords

chemotherapyimmune responseimmunotherapyavascular tumourvaccine therapy

Mathematics Subject Classification ID

Medical applications (general) (92C50)

Abstract: We formulate and analyze a mathematical model describing immune response to avascular tumor under the influence of immunotherapy and chemotherapy and their combinations as well as vaccine treatments. The effect of vaccine therapy is considered as a parametric perturbation of the model. In the case of a weak immune response, neither immunotherapy nor chemotherapy is found to cause tumor regression to a small size, which would be below the clinically detectable threshold. Numerical simulations show that the efficiency of vaccine therapy depends on both the tumor size and the condition of immune system as well as on the response of the organism to vaccination. In particular, we found that vaccine therapy becomes more effective when used without time delay from a prescribed date of vaccination after surgery and is ineffective without preliminary treatment. For a strong immune response, our model predicts the tumor remission under vaccine therapy. Our study of successive chemo/immuno, immuno/chemo and concurrent chemoimmunotherapy shows that the chemo/immuno sequence is more effective while concurrent chemoimmunotherapy is more sparing.

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Cited in

(12)

• On a multiobjective optimal control of a tumor growth model with immune response and drug therapies
• Efficiency of cancer treatments: \textit{in silico experiments}
• In silico synergism and antagonism of an anti-tumour system intervened by coupling immunotherapy and chemotherapy: a mathematical modelling approach
• Computational modeling of the immune response to tumor antigens
• Optimal control problem for a general reaction-diffusion tumor-immune interaction system of mixed immunotherapy and chemotherapy
• The effect of finite duration inputs on the dynamics of a system: proposing a new approach for cancer treatment
• scientific article; zbMATH DE number 1303463 (Why is no real title available?)
• Optimal control for selected cancer chemotherapy ODE models: a view on the potential of optimal schedules and choice of objective function
• Memory effects on the proliferative function in the cycle-specific of chemotherapy
• A novel method for simulating the extracellular matrix in models of tumour growth
• Modelling of tumor cells regression in response to chemotherapeutic treatment
• The pulse vaccination effects in mammary carcinoma

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