Significant residue features revealed by eigenvalue decomposition analysis of BLOSUM matrices

DOI10.1016/J.PHYSLETA.2007.10.091MaRDI QIDQ637284zbMATH OpenOpenAlexFDO

Authors Xin Liu, Li-mei Zhang

Publication date 2 September 2011

Published in Physics Letters. A (Search for Journal in Brave)

Full work available at URL http://dspace.imech.ac.cn/handle/311007/26084

zbMATH Keywords

BLOSUMeigenvalue decompositionprotein evolutionresidue feature

Mathematics Subject Classification ID

Selfadjoint operator theory in quantum theory, including spectral analysis (81Q10) Molecular physics (81V55) Statistical mechanics of liquids (82D15) Statistical mechanics of solids (82D20) Biochemistry, molecular biology (92C40)

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• Donut-shaped fingerprint in homologous polypeptide relationships -- a topological feature related to pathogenic structural changes in conformational disease
• Solvent accessibility, residue charge and residue volume, the three ingredients of a robust amino acid substitution matrix

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