Statistical Methods for Identifying Conserved Residues in Multiple Sequence Alignment

DOI10.2202/1544-6115.1074MaRDI QIDQ5700473zbMATH OpenOpenAlexWikidataFDO

Authors Virpi Ahola, Tero Aittokallio, Esa Uusipaikka, M. Vihinen

Publication date 28 October 2005

Published in Statistical Applications in Genetics and Molecular Biology (Search for Journal in Brave)

Full work available at URL http://www.bepress.com/sagmb/vol3/iss1/art28/

Mathematics Subject Classification ID

Paired and multiple comparisons; multiple testing (62J15) Applications of statistics to biology and medical sciences; meta analysis (62P10) Biochemistry, molecular biology (92C40)

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• Several appropriate background distributions for entropy-based protein sequence conservation measures
• Entangled effects of two consecutive pairs in residues and its use in alignment
• A Statistical Method for Comparison of Two Structures and Its Biological Applications
• An improved approximation for assessing the statistical significance of molecular sequence features
• Development of novel classical and quantum information theory based methods for the detection of compensatory mutations in MSAs
• Significant residue features revealed by eigenvalue decomposition analysis of BLOSUM matrices

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