A method for visual identification of small sample subgroups and potential biomarkers

DOI10.1214/11-AOAS460MaRDI QIDQ652375zbMATH OpenOpenAlexFDO

Authors Charlotte Soneson, Magnus Fontes

Publication date 14 December 2011

Published in The Annals of Applied Statistics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1111.7125

zbMATH Keywords

dimension reductionvisualizationmultidimensional scalingprincipal components analysisbiplot

Mathematics Subject Classification ID

Factor analysis and principal components; correspondence analysis (62H25) Multivariate analysis (62H99) Applications of statistics to biology and medical sciences; meta analysis (62P10)

Abstract: In order to find previously unknown subgroups in biomedical data and generate testable hypotheses, visually guided exploratory analysis can be of tremendous importance. In this paper we propose a new dissimilarity measure that can be used within the Multidimensional Scaling framework to obtain a joint low-dimensional representation of both the samples and variables of a multivariate data set, thereby providing an alternative to conventional biplots. In comparison with biplots, the representations obtained by our approach are particularly useful for exploratory analysis of data sets where there are small groups of variables sharing unusually high or low values for a small group of samples.

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Cites work

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• A method for visual identification of small sample subgroups and potential biomarkers
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Cited in

(3)

• Measuring and visualizing the stability of biomarker selection techniques
• A method for visual identification of small sample subgroups and potential biomarkers
• REPRESENTING THE RESULTS OF SUBGROUP ANALYSIS IN COMPARATIVE CLINICAL STUDIES BY A GRAPH

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