The Michaelis-Menten reaction at low substrate concentrations: pseudo-first-order kinetics and conditions for timescale separation

DOI10.1007/S11538-024-01295-ZMaRDI QIDQ6540667zbMATH OpenFDO

Authors Justin S. Eilertsen, Santiago Schnell, S Walcher

Publication date 17 May 2024

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1007/S11538-024-01295-Z

zbMATH Keywords

comparison principlemonotone dynamical systempseudo-first-order kineticstotal quasi-steady state approximation

Mathematics Subject Classification ID

Monotone systems involving ordinary differential equations (34C12) Singular perturbations for ordinary differential equations (34E15) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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Cites work

• A constructive approach to quasi-steady state reductions
• Extending the quasi-steady state approximation by changing variables
• scientific article; zbMATH DE number 758785 (Why is no real title available?)
• Introducing total substrates simplifies theoretical analysis at non-negligible enzyme concentrations: pseudo first-order kinetics and the loss of zero-order ultrasensitivity
• Mathematical physiology. I: Cellular physiology
• Monotone chemical reaction networks
• On the anti-quasi-steady-state conditions of enzyme kinetics
• On the Structure of Local Homeomorphisms of Euclidean n-Space, II
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• Parameter Estimation for Differential Equations: a Generalized Smoothing Approach
• Systems of Differential Equations Which Are Competitive or Cooperative: I. Limit Sets
• The Quasi-Steady-State Assumption: A Case Study in Perturbation
• The unreasonable effectiveness of the total quasi-steady state approximation, and its limitations
• Zur Theorie der Systeme gewöhnlicher Differentialgleichungen. II

Cited in

(1)

• The unique equilibrium's global exponential asymptotic stability of the irreversible Michaelis-Menten mechanism of enzyme kinetics

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