Evaluation of early phase dose finding algorithms in heterogeneous populations

DOI10.1016/J.JSPI.2023.05.003MaRDI QIDQ6541920zbMATH OpenFDO

Authors Matthieu Clertant, Alexia Iasonos, John O'Quigley

Publication date 21 May 2024

Published in Journal of Statistical Planning and Inference (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/J.JSPI.2023.05.003

zbMATH Keywords

causal inferenceclinical trialsdose escalationdose finding studiesexperimental designmatched comparisonsreproducibilitytoxicity

Mathematics Subject Classification ID

Statistics (62-XX)

Cites work

• Bayesian optimal interval designs for phase I clinical trials
• Causal inference for statistics, social, and biomedical sciences. An introduction
• Continual Reassessment Method: A Likelihood Approach
• Cumulative cohort design for dose-finding
• Non-parametric optimal design in dose finding studies
• Semiparametric Dose Finding Methods
• The treatment versus experimentation dilemma in dose finding studies

Cited in

(2)

• Dual-agent dose-finding in phase I clinical trial -- an extension of rapid enrollment design
• Causal inference in early phase clinical trials: variance decomposition and order of patient inclusion

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