Adaptive multiarm multistage clinical trials

DOI10.1002/SIM.8464MaRDI QIDQ6627520zbMATH OpenWikidataFDO

Authors Pranab Ghosh, Lingyun Liu, Cyrus R. Mehta

Publication date 29 October 2024

Published in Statistics in Medicine (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1002/SIM.8464

zbMATH Keywords

\(P\)-value combinationadaptive Dunnettadaptive MAMSclosed testingcumulative MAMSDunnettearly stoppingFWERMAMSmultistage designpairwise comparisonsample size reestimationseamless phase 2--3treatment selectiontwo-stage design

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10)

Cites work

• A comparison of methods for adaptive treatment selection
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• On closed testing procedures with special reference to ordered analysis of variance
• Simultaneous confidence intervals that are compatible with closed testing in adaptive designs
• Uniformly minimum variance conditionally unbiased estimation in multi-arm multi-stage clinical trials

Cited in

(4)

• Group sequential multi-arm multi-stage trial design with treatment selection
• Group sequential Holm and Hochberg procedures
• Graph based, adaptive, multiarm, multiple endpoint, two-stage designs
• A comparison of two methods for adaptive multi-arm two-stage design

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