Impact of latently infected cells on strain archiving within HIV hosts

DOI10.1007/S11538-012-9742-0MaRDI QIDQ692472zbMATH OpenOpenAlexWikidataFDO

Authors Zoë Ward, Jane White

Publication date 6 December 2012

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s11538-012-9742-0

zbMATH Keywords

drug resistancelatent cellslow-level viral load

Mathematics Subject Classification ID

Medical applications (general) (92C50) Probabilistic models, generic numerical methods in probability and statistics (65C20)

Recommendations

• Stochastic dynamics of the latently infected cell reservoir during HIV infection
• Asymmetric division of activated latently infected cells may explain the decay kinetics of the HIV-1 latent reservoir and intermittent viral blips
• Reducing the latent CD4\(^+\) cells reservoirs in HIV infection with optimal HAART therapy
• The effects of latent infection on the dynamics of HIV
• Can the viral reservoir of latently infected \(CD4^{+}\) T cells be eradicated with antiretroviral HIV drugs?

Cites work

• Asymmetric division of activated latently infected cells may explain the decay kinetics of the HIV-1 latent reservoir and intermittent viral blips
• Drug concentration heterogeneity facilitates the evolution of drug resistance
• Dynamics of HIV infection of CD4\(^ +\) T cells
• Emergence of HIV-1 drug resistance during antiretroviral treatment
• HIV-1 infection and low steady state viral loads
• Modeling HIV persistence, the latent reservoir, and viral blips
• Opportunistic infection as a cause of transient viremia in chronically infected HIV patients under treatment with HAART

Cited in

(2)

• Latently infected cell activation: a way to reduce the size of the HIV reservoir?
• Dynamical analysis of antigen-driven t-cell infection model with multiple delays

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