A two-way regularization method for MEG source reconstruction

DOI10.1214/11-AOAS531zbMATH Open1254.92059arXiv1209.6443OpenAlexW3098382855MaRDI QIDQ714359FDOQ714359

Authors: Tian Siva Tian, Jianhua Z. Huang, Haipeng Shen, Zhimin Li 

Publication date: 21 October 2012

Published in: The Annals of Applied Statistics (Search for Journal in Brave)

Abstract: The MEG inverse problem refers to the reconstruction of the neural activity of the brain from magnetoencephalography (MEG) measurements. We propose a two-way regularization (TWR) method to solve the MEG inverse problem under the assumptions that only a small number of locations in space are responsible for the measured signals (focality), and each source time course is smooth in time (smoothness). The focality and smoothness of the reconstructed signals are ensured respectively by imposing a sparsity-inducing penalty and a roughness penalty in the data fitting criterion. A two-stage algorithm is developed for fast computation, where a raw estimate of the source time course is obtained in the first stage and then refined in the second stage by the two-way regularization. The proposed method is shown to be effective on both synthetic and real-world examples.

Full work available at URL: https://arxiv.org/abs/1209.6443

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zbMATH Keywords

inverse problemspatio-temporaltwo-way regularization

Mathematics Subject Classification ID

Linear regression; mixed models (62J05) Neural biology (92C20) Biomedical imaging and signal processing (92C55) Software, source code, etc. for problems pertaining to biology (92-04)

Cites Work

• The analysis of two-way functional data using two-way regularized singular value decompositions
• Title not available (Why is that?)
• Sparse principal component analysis via regularized low rank matrix approximation
• Functional principal components analysis via penalized rank one approximation
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• Biclustering via sparse singular value decomposition
• Estimating evoked dipole responses in unknown spatially correlated noise with EEG/ MEG arrays

Cited In (9)

• Scalable spatio‐temporal Bayesian analysis of high‐dimensional electroencephalography data
• Estimating a common period for a set of irregularly sampled functions with applications to periodic variable star data
• A new approach to the MEG/EEG inverse problem for the recovery of cortical phase-synchrony
• Multi-dimensional functional principal component analysis
• Dynamic filtering of static dipoles in magnetoencephalography
• Local-aggregate modeling for big data via distributed optimization: applications to neuroimaging
• Representation and reconstruction of covariance operators in linear inverse problems
• Two-way regularization for MEG source reconstruction via multilevel coordinate descent
• Quasi-periodic spatiotemporal models of brain activation in single-trial <scp>MEG</scp> experiments

Uses Software

• BRENT
• PMA

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