Derivation of the bacterial run-and-tumble kinetic equation from a model with biochemical pathway

DOI10.1007/S00285-016-0985-5zbMATH Open1358.35207arXiv1503.03979OpenAlexW1790951631WikidataQ50688696 ScholiaQ50688696MaRDI QIDQ728542FDOQ728542

Authors: Min Tang, Nicolas Vauchelet, Ben{ôı}t Perthame 

Publication date: 20 December 2016

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Abstract: Kinetic-transport equations are, by now, standard models to describe the dynamics of populations of bacteria moving by run-and-tumble. Experimental observations show that bacteria increase their run duration when encountering an increasing gradient of chemotactic molecules. This led to a first class of models which heuristically include tumbling frequencies depending on the path-wise gradient of chemotactic signal. More recently, the biochemical pathways regulating the flagellar motors were uncovered. This knowledge gave rise to a second class of kinetic-transport equations, that takes into account an intra-cellular molecular content and which relates the tumbling frequency to this information. It turns out that the tumbling frequency depends on the chemotactic signal, and not on its gradient. For these two classes of models, macroscopic equations of Keller-Segel type, have been derived using diffusion or hyperbolic rescaling. We complete this program by showing how the first class of equations can be derived from the second class with molecular content after appropriate rescaling. The main difficulty is to explain why the path-wise gradient of chemotactic signal can arise in this asymptotic process. Randomness of receptor methylation events can be included, and our approach can be used to compute the tumbling frequency in presence of such a noise.

Full work available at URL: https://arxiv.org/abs/1503.03979

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zbMATH Keywords

asymptotic analysischemotaxisbiochemical pathwayrun and tumblekinetic-transport equations

Mathematics Subject Classification ID

Asymptotic behavior of solutions to PDEs (35B40) Kinetic theory of gases in time-dependent statistical mechanics (82C40) Singular perturbations in context of PDEs (35B25) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Cell movement (chemotaxis, etc.) (92C17)

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Cited In (27)

• Stiff-response-induced instability for chemotactic bacteria and flux-limited Keller-Segel equation
• Numerical Scheme for Kinetic Transport Equation with Internal State
• Individual based models exhibiting Lévy-flight type movement induced by intracellular noise
• Trend to equilibrium for run and tumble equations with non-uniform tumbling kernels
• Travelling chemotactic aggregates at mesoscopic scale and bistability
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• Mesoscopic models in biology
• Models of cell motion and tissue growth
• The fractional diffusion limit of a kinetic model with biochemical pathway
• Global solution for a kinetic chemotaxis model with internal dynamics and its fast adaptation limit
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• Concentration waves of chemotactic bacteria: the discrete velocity case
• Macroscopic limits of pathway-based kinetic models for E. coli chemotaxis in large gradient environments
• On the Asymptotic Behavior of a Run and Tumble Equation for Bacterial Chemotaxis
• Multiscale modeling of glioma pseudopalisades: contributions from the tumor microenvironment
• Fractional Patlak-Keller-Segel equations for chemotactic superdiffusion
• Kinetic and macroscopic models for active particles exploring complex environments with an internal navigation control system
• Mathematical modeling of glioma invasion: acid- and vasculature mediated go-or-grow dichotomy and the influence of tissue anisotropy
• Numerical study of the volcano effect in chemotactic aggregation based on a kinetic transport equation with non-instantaneous tumbling
• A kinetic chemotaxis model with internal states and temporal sensing
• Large coupling in a FitzHugh-Nagumo neural network: quantitative and strong convergence results
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• Monte Carlo simulation for kinetic chemotaxis model: an application to the traveling population wave
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