Persistence of direction increases the drift velocity of run and tumble chemotaxis

DOI10.1007/S00285-007-0080-ZzbMATH Open1141.92008arXiv0706.3589OpenAlexW1990401992WikidataQ51920657 ScholiaQ51920657MaRDI QIDQ938071FDOQ938071

J. T. Locsei

Publication date: 18 August 2008

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Abstract: Escherichia coli is a motile bacterium that moves up a chemoattractant gradient by performing a biased random walk composed of alternating runs and tumbles. Previous models of run and tumble chemotaxis neglect one or more features of the motion, namely (i) a cell cannot directly detect a chemoattractant gradient but rather makes temporal comparisons of chemoattractant concentration, (ii) rather than being entirely random, tumbles exhibit persistence of direction, meaning that the new direction after a tumble is more likely to be in the forward hemisphere, and (iii) rotational Brownian motion makes it impossible for an E. coli cell to swim in a straight line during a run. This paper presents an analytic calculation of the chemotactic drift velocity taking account of (i), (ii) and (iii), for weak chemotaxis. The analytic results are verified by Monte Carlo simulation. The results reveal a synergy between temporal comparisons and persistence that enhances the drift velocity, while rotational Brownian motion reduces the drift velocity.

Full work available at URL: https://arxiv.org/abs/0706.3589

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zbMATH Keywords

Brownian motionchemotaxisrandom walksEscherichia coli

Mathematics Subject Classification ID

Monte Carlo methods (65C05) Applications of Brownian motions and diffusion theory (population genetics, absorption problems, etc.) (60J70) Cell movement (chemotaxis, etc.) (92C17)

Cites Work

• Random walk with persistence and external bias
• From Signal Transduction to Spatial Pattern Formation inE. coli: A Paradigm for Multiscale Modeling in Biology
• Gravitaxis in motile micro-organisms: the role of fore–aft body asymmetry

Cited In (11)

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• A path-integral characterization of run and tumble motion and chemotaxis of bacteria
• Modeling and analysis of melanoblast motion
• A diffusion approximation based on renewal processes with applications to strongly biased run-tumble motion
• Run and tumble chemotaxis in a shear flow: the effect of temporal comparisons, persistence, rotational diffusion, and cell shape
• Directional persistence and the optimality of run-and-tumble chemotaxis
• The role of tumbling frequency and persistence in optimal run-and-tumble chemotaxis
• Monte Carlo simulation for kinetic chemotaxis model: an application to the traveling population wave
• First passage statistics of active random walks on one and two dimensional lattices
• Derivation of the bacterial run-and-tumble kinetic equation from a model with biochemical pathway
• Confinement by biased velocity jumps: aggregation of \textit{Escherichia coli}

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