Persistence of direction increases the drift velocity of run and tumble chemotaxis

DOI10.1007/S00285-007-0080-ZMaRDI QIDQ938071zbMATH OpenOpenAlexWikidataFDO

Authors J. T. Locsei

Publication date 18 August 2008

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/0706.3589

zbMATH Keywords

Brownian motionchemotaxisEscherichia colirandom walks

Mathematics Subject Classification ID

Applications of Brownian motions and diffusion theory (population genetics, absorption problems, etc.) (60J70) Monte Carlo methods (65C05) Cell movement (chemotaxis, etc.) (92C17)

Abstract: Escherichia coli is a motile bacterium that moves up a chemoattractant gradient by performing a biased random walk composed of alternating runs and tumbles. Previous models of run and tumble chemotaxis neglect one or more features of the motion, namely (i) a cell cannot directly detect a chemoattractant gradient but rather makes temporal comparisons of chemoattractant concentration, (ii) rather than being entirely random, tumbles exhibit persistence of direction, meaning that the new direction after a tumble is more likely to be in the forward hemisphere, and (iii) rotational Brownian motion makes it impossible for an E. coli cell to swim in a straight line during a run. This paper presents an analytic calculation of the chemotactic drift velocity taking account of (i), (ii) and (iii), for weak chemotaxis. The analytic results are verified by Monte Carlo simulation. The results reveal a synergy between temporal comparisons and persistence that enhances the drift velocity, while rotational Brownian motion reduces the drift velocity.

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Cites work

• From Signal Transduction to Spatial Pattern Formation inE. coli: A Paradigm for Multiscale Modeling in Biology
• Gravitaxis in motile micro-organisms: the role of fore–aft body asymmetry
• Random walk with persistence and external bias

Cited in

(14)

• Directional persistence and the optimality of run-and-tumble chemotaxis
• Monte Carlo simulation for kinetic chemotaxis model: an application to the traveling population wave
• Theoretical results for chemotactic response and drift of \textit{E. coli} in a weak attractant gradient
• Modeling and analysis of melanoblast motion
• Confinement by biased velocity jumps: aggregation of \textit{Escherichia coli}
• A diffusion approximation based on renewal processes with applications to strongly biased run-tumble motion
• The role of tumbling frequency and persistence in optimal run-and-tumble chemotaxis
• First passage statistics of active random walks on one and two dimensional lattices
• A model of strongly biased chemotaxis reveals the trade-offs of different bacterial migration strategies
• A path-integral characterization of run and tumble motion and chemotaxis of bacteria
• Molecular and functional aspects of bacterial chemotaxis
• Bacterial chemotaxis in a traveling wave attractant environment
• Derivation of the bacterial run-and-tumble kinetic equation from a model with biochemical pathway
• Run and tumble chemotaxis in a shear flow: the effect of temporal comparisons, persistence, rotational diffusion, and cell shape

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