An algebraic hypothesis about the primeval genetic code architecture

DOI10.1016/J.MBS.2009.07.001MaRDI QIDQ733255zbMATH OpenOpenAlexWikidataFDO

Authors Robersy Sánchez, Ricardo Grau

Publication date 15 October 2009

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/0805.1128

zbMATH Keywords

evolutionary modelgene mutationgenetic code algebragenetic code vector spaceprimeval DNAprimeval genetic code

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Problems related to evolution (92D15) Separable extensions, Galois theory (12F10)

Abstract: A plausible architecture of an ancient genetic code is derived from an extended base triplet vector space over the Galois field of the extended base alphabet {D, G, A, U, C}, where the letter D represents one or more hypothetical bases with unspecific pairing. We hypothesized that the high degeneration of a primeval genetic code with five bases and the gradual origin and improvements of a primitive DNA repair system could make possible the transition from the ancient to the modern genetic code. Our results suggest that the Watson-Crick base pairing and the non-specific base pairing of the hypothetical ancestral base D used to define the sum and product operations are enough features to determine the coding constraints of the primeval and the modern genetic code, as well as, the transition from the former to the later. Geometrical and algebraic properties of this vector space reveal that the present codon assignment of the standard genetic code could be induced from a primeval codon assignment.Besides, the Fourier spectrum of the extended DNA genome sequences derived from the multiple sequence alignment suggests that the called period-3 property of the present coding DNA sequences could also exist in the ancient coding DNA sequences.

Recommendations

• Some algebraic aspects and evolution of genetic code
• An extended RNA code and its relationship to the standard genetic code: An algebraic and geometrical approach
• scientific article; zbMATH DE number 4008167
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Cites work

• scientific article; zbMATH DE number 1945176 (Why is no real title available?)
• A novel Lie algebra of the genetic code over the Galois field of four DNA bases
• Extended and multivariate Tukey lambda distributions
• Gene algebra from a genetic code algebraic structure
• Statististical methods in molecular evolution.

Cited in

(4)

• Perspectives in the algebraic approach to the genetic code
• Translocation properties of primitive molecular machines and their relevance to the structure of the genetic code
• Genetic Hotels for the standard genetic code: evolutionary analysis based upon novel three-dimensional algebraic models
• An extended RNA code and its relationship to the standard genetic code: An algebraic and geometrical approach

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