Vascular phenotype identification and anti-angiogenic treatment recommendation: a pseudo-multiscale mathematical model of angiogenesis

DOI10.1016/J.JTBI.2016.03.002MaRDI QIDQ738575zbMATH OpenOpenAlexWikidataFDO

Authors L. G. Hutchinson, J. Wagg, A. Phipps, H. M. Byrne, Eamonn A. Gaffney, Philip K. Maini

Publication date 5 September 2016

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2016.03.002

zbMATH Keywords

ordinary differential equationlinear stabilityvessel normalisation

Mathematics Subject Classification ID

Medical applications (general) (92C50) Developmental biology, pattern formation (92C15)

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Cites work

• A continuous model of angiogenesis: initiation, extension, and maturation of new blood vessels modulated by vascular endothelial growth factor, angiopoietins, platelet-derived growth factor-B, and pericytes
• A mathematical model for the roles of pericytes and macrophages in the initiation of angiogenesis. I: The role of protease inhibitors in preventing angiogenesis
• A mathematical model of tumour angiogenesis, regulated by vascular endothelial growth factor and the angiopoietins
• A pharmacologically based multiscale mathematical model of angiogenesis and its use in investigating the efficacy of a new cancer treatment strategy
• A review of mathematical models for the formation of vascular networks
• Angiogenesis and vascular remodelling in normal and cancerous tissues
• Hopf point analysis for angiogenesis models
• MODELLING THE RESPONSE OF VASCULAR TUMOURS TO CHEMOTHERAPY: A MULTISCALE APPROACH
• Mathematical modelling of flow in 2D and 3D vascular networks: Applications to anti-angio\-genic and chemotherapeutic drug strategies
• Modeling the VEGF-Bcl-2-CXCL8 pathway in intratumoral agiogenesis
• Theoretical investigation of the efficacy of antiangiogenic drugs combined to chemotherapy in xenografted mice
• Vascular network remodeling via vessel cooption, regression and growth in tumors
• Vascular remodelling of an arterio-venous blood vessel network during solid tumour growth

Cited in

(5)

• Mathematical modeling of cellular cross-talk between endothelial and tumor cells highlights counterintuitive effects of VEGF-targeted therapies
• Model prediction and validation of an order mechanism controlling the spatiotemporal phenotype of early hepatocellular carcinoma
• Multi-scale analysis of angiogenic dynamics and therapy
• A novel nonlocal partial differential equation model of endothelial progenitor cell cluster formation during the early stages of vasculogenesis
• Mathematical modelling of flow in 2D and 3D vascular networks: Applications to anti-angio\-genic and chemotherapeutic drug strategies

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