Vascular network remodeling via vessel cooption, regression and growth in tumors
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Publication:2199287
DOI10.1016/J.JTBI.2006.01.022zbMATH Open1447.92083arXivq-bio/0506039OpenAlexW2165673724WikidataQ82869343 ScholiaQ82869343MaRDI QIDQ2199287FDOQ2199287
Authors: Yanyan Li 
Publication date: 16 September 2020
Published in: Journal of Theoretical Biology (Search for Journal in Brave)
Abstract: The transformation of the regular vasculature in normal tissue into a highly inhomogeneous tumor specific capillary network is described by a theoretical model incorporating tumor growth, vessel cooption, neo-vascularization, vessel collapse and cell death. Compartmentalization of the tumor into several regions differing in vessel density, diameter and in necrosis is observed for a wide range of parameters in agreement with the vessel morphology found in human melanoma. In accord with data for human melanoma the model predicts, that microvascular density (MVD, regarded as an important diagnostic tool in cancer treatment, does not necessarily determine the tempo of tumor progression. Instead it is suggested, that the MVD of the original tissue as well as the metabolic demand of the individual tumor cell plays the major role in the initial stages of tumor growth.
Full work available at URL: https://arxiv.org/abs/q-bio/0506039
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Cites Work
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Cited In (24)
- On optimal delivery of combination therapy for tumors
- A computational model of intussusceptive microvascular growth and remodeling
- Computational modeling of tumor-induced angiogenesis
- Pharmacokinetic/pharmacodynamic modeling of combination-chemotherapy for lung cancer
- A pharmacologically based multiscale mathematical model of angiogenesis and its use in investigating the efficacy of a new cancer treatment strategy
- Modelling tumour cell proliferation from vascular structure using tissue decomposition into avascular elements
- Vascular phenotype identification and anti-angiogenic treatment recommendation: a pseudo-multiscale mathematical model of angiogenesis
- An optimization based 3D-1D coupling strategy for tissue perfusion and chemical transport during tumor-induced angiogenesis
- Coupled modelling of tumour angiogenesis, tumour growth and blood perfusion
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- Mathematical model and its fast numerical method for the tumor growth
- Role of vascular smooth muscle cell phenotypic switching in plaque progression: a hybrid modeling study
- Angiogenesis and vascular remodelling in normal and cancerous tissues
- Macro-scale models for fluid flow in tumour tissues: impact of microstructure properties
- Angiogenesis model with Erlang distributed delays
- Theoretical investigation of the efficacy of antiangiogenic drugs combined to chemotherapy in xenografted mice
- An adaptive multigrid algorithm for simulating solid tumor growth using mixture models
- Gibbs point field model quantifies disorder in microvasculature of U87-glioblastoma
- Vascular remodelling of an arterio-venous blood vessel network during solid tumour growth
- How tumour-induced vascular changes alter angiogenesis: insights from a computational model
- The effect of interstitial pressure on tumor growth: coupling with the blood and lymphatic vascular systems
- A review of mathematical models for the formation of vascular networks
- Three-dimensional multispecies nonlinear tumor growth. II: Tumor invasion and angiogenesis
- Three-dimensional multispecies nonlinear tumor growth. I: Model and numerical method
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