Vascular network remodeling via vessel cooption, regression and growth in tumors
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Publication:2199287
Abstract: The transformation of the regular vasculature in normal tissue into a highly inhomogeneous tumor specific capillary network is described by a theoretical model incorporating tumor growth, vessel cooption, neo-vascularization, vessel collapse and cell death. Compartmentalization of the tumor into several regions differing in vessel density, diameter and in necrosis is observed for a wide range of parameters in agreement with the vessel morphology found in human melanoma. In accord with data for human melanoma the model predicts, that microvascular density (MVD, regarded as an important diagnostic tool in cancer treatment, does not necessarily determine the tempo of tumor progression. Instead it is suggested, that the MVD of the original tissue as well as the metabolic demand of the individual tumor cell plays the major role in the initial stages of tumor growth.
Recommendations
- Vascular remodelling of an arterio-venous blood vessel network during solid tumour growth
- Emergent vascular network inhomogeneities and resulting blood flow patterns in a growing tumor
- Modeling Tumor Blood Vessel Dynamics
- Mathematical modeling of capillary formation and development in tumor angiogenesis: penetration into the stroma
- Angiogenesis and vascular remodelling in normal and cancerous tissues
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