A multi-scale mathematical modeling framework to investigate anti-viral therapeutic opportunities in targeting HIV-1 accessory proteins

DOI10.1016/J.JTBI.2015.08.032zbMATH Open1343.92174OpenAlexW1625086967WikidataQ36387986 ScholiaQ36387986MaRDI QIDQ739788FDOQ739788

Authors: Gajendra W. Suryawanshi, Alexander Hoffmann 

Publication date: 19 August 2016

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://escholarship.org/uc/item/42s7569v

Recommendations

• Quantifying the antiviral effect of APOBEC3 on HIV-1 infection in humanized mouse model
• Modelling the immunopathogenesis of HIV-1 infection and the effect of multidrug therapy: the role of fusion inhibitors in HAART
• Studying HIV latency by modeling the interaction between HIV proteins and the innate immune response
• Modeling the role of acquired immune response and antiretroviral therapy in the dynamics of HIV infection
• An in-depth analysis of the HIV-1/AIDS dynamics by comprehensive mathematical modeling

zbMATH Keywords

age-structured modelscombination therapyhost restriction factorshypermutationsreproductive ratio

Mathematics Subject Classification ID

Medical applications (general) (92C50) Biochemistry, molecular biology (92C40)

Cites Work

• Modeling HIV persistence, the latent reservoir, and viral blips
• Mathematical Analysis of Age‐Structured HIV‐1 Dynamics with Combination Antiretroviral Therapy
• Optimizing within-host viral fitness: infected cell lifespan and virion production rate
• An age-structured model of HIV infection that allows for variations in the production rate of viral particles and the death rate of productively infected cells
• A model for treatment strategy in the chemotherapy of AIDS
• Mathematical Modeling of HIV-1 Infection and Drug Therapy

Cited In (4)

• Dynamical analysis and optimal control of an age-since infection HIV model at individuals and population levels
• HIV-1 integrase-DNA interactions investigated by molecular modelling
• Global dynamics of an age-space structured HIV/AIDS model with viral load-dependent infection and conversion rates
• Mathematical analysis of an age-structured HIV-1 infection model with CTL immune response

This page was built for publication: A multi-scale mathematical modeling framework to investigate anti-viral therapeutic opportunities in targeting HIV-1 accessory proteins

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q739788)