A multi-scale mathematical modeling framework to investigate anti-viral therapeutic opportunities in targeting HIV-1 accessory proteins

DOI10.1016/J.JTBI.2015.08.032MaRDI QIDQ739788zbMATHOpenAlexWikidataFDO

Authors Gajendra W. Suryawanshi, Alexander Hoffmann

Publication date 19 August 2016

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://escholarship.org/uc/item/42s7569v

zbMATH Keywords

age-structured modelscombination therapyhost restriction factorshypermutationsreproductive ratio

Mathematics Subject Classification ID

Medical applications (general) (92C50) Biochemistry, molecular biology (92C40)

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Cites work

• A model for treatment strategy in the chemotherapy of AIDS
• An age-structured model of HIV infection that allows for variations in the production rate of viral particles and the death rate of productively infected cells
• Mathematical Analysis of Age‐Structured HIV‐1 Dynamics with Combination Antiretroviral Therapy
• Mathematical modeling of HIV-1 infection and drug therapy
• Modeling HIV persistence, the latent reservoir, and viral blips
• Optimizing within-host viral fitness: infected cell lifespan and virion production rate

Cited in

(7)

• HIV-1 integrase-DNA interactions investigated by molecular modelling
• Global dynamics of an age-space structured HIV/AIDS model with viral load-dependent infection and conversion rates
• Mathematical analysis of an age-structured HIV-1 infection model with CTL immune response
• Quantifying the antiviral effect of APOBEC3 on HIV-1 infection in humanized mouse model
• Dynamical analysis and optimal control of an age-since infection HIV model at individuals and population levels
• Studying HIV latency by modeling the interaction between HIV proteins and the innate immune response
• Maternal embryonic leucine zipper kinase (MELK) optimally regulates the HIV-1 uncoating process

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