Splitting trees with neutral Poissonian mutations. I: Small families

DOI10.1016/J.SPA.2011.11.002zbMATH Open1255.60153arXiv1009.0680OpenAlexW2110421859MaRDI QIDQ765886FDOQ765886

Authors: Nicolas Champagnat, Amaury Lambert 

Publication date: 22 March 2012

Published in: Stochastic Processes and their Applications (Search for Journal in Brave)

Abstract: We consider a neutral dynamical model of biological diversity, where individuals live and reproduce independently. They have i.i.d. lifetime durations (which are not necessarily exponentially distributed) and give birth (singly) at constant rate b. Such a genealogical tree is usually called a splitting tree, and the population counting process (N_t;tge 0) is a homogeneous, binary Crump--Mode--Jagers process. We assume that individuals independently experience mutations at constant rate heta during their lifetimes, under the infinite-alleles assumption: each mutation instantaneously confers a brand new type, called allele, to its carrier. We are interested in the allele frequency spectrum at time t, i.e., the number A(t) of distinct alleles represented in the population at time t, and more specifically, the numbers A(k,t) of alleles represented by k individuals at time t, k=1,2,...,N_t. We mainly use two classes of tools: coalescent point processes and branching processes counted by random characteristics. We provide explicit formulae for the expectation of A(k,t) in a coalescent point process conditional on population size, which apply to the special case of splitting trees. We separately derive the a.s. limits of A(k,t)/N_t and of A(t)/N_t thanks to random characteristics. Last, we separately compute the expected homozygosity by applying a method characterizing the dynamics of the tree distribution as the origination time of the tree moves back in time, in the spirit of backward Kolmogorov equations.

Full work available at URL: https://arxiv.org/abs/1009.0680

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zbMATH Keywords

coalescent point processscale functionsplitting treebranching processPoisson point processCrump-Mode-Jagers processlinear birth-death processregenerative setrandom characteristicLévy process

Mathematics Subject Classification ID

Genetics and epigenetics (92D10) Markov chains (discrete-time Markov processes on discrete state spaces) (60J10) Branching processes (Galton-Watson, birth-and-death, etc.) (60J80)

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Cited In (17)

• Species abundance distributions in neutral models with immigration or mutation and general lifetimes
• Further properties of a random graph with duplications and deletions
• Approximation of the allelic frequency spectrum in general supercritical branching populations
• Random ultrametric trees and applications
• Genetic composition of an exponentially growing cell population
• Some properties of the conditioned reconstructed process with Bernoulli sampling
• Mutational pattern of a sample from a critical branching population
• Moments of the frequency spectrum of a splitting tree with neutral Poissonian mutations
• Splitting trees with neutral mutations at birth
• Central limit theorem for supercritical binary homogeneous Crump-Mode-Jagers processes
• The allelic partition for coalescent point processes
• Mutations on a random binary tree with measured boundary
• Statistics of branched populations split into different types
• Birth and death processes with neutral mutations
• Splitting trees with neutral Poissonian mutations. II: Largest and oldest families
• Asymptotic degree distribution of a duplication-deletion random graph model
• Splitting Trees Stopped when the First Clock Rings and Vervaat's Transformation

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