Splitting trees with neutral Poissonian mutations. I: Small families

DOI10.1016/J.SPA.2011.11.002MaRDI QIDQ765886zbMATH OpenOpenAlexFDO

Authors Nicolas Champagnat, Amaury Lambert

Publication date 22 March 2012

Published in Stochastic Processes and their Applications (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1009.0680

zbMATH Keywords

branching processcoalescent point processCrump-Mode-Jagers processlinear birth-death processLévy processPoisson point processrandom characteristicregenerative setscale functionsplitting tree

Mathematics Subject Classification ID

Markov chains (discrete-time Markov processes on discrete state spaces) (60J10) Branching processes (Galton-Watson, birth-and-death, etc.) (60J80) Genetics and epigenetics (92D10)

Abstract: We consider a neutral dynamical model of biological diversity, where individuals live and reproduce independently. They have i.i.d. lifetime durations (which are not necessarily exponentially distributed) and give birth (singly) at constant rate b. Such a genealogical tree is usually called a splitting tree, and the population counting process (N_t;tge 0) is a homogeneous, binary Crump--Mode--Jagers process. We assume that individuals independently experience mutations at constant rate heta during their lifetimes, under the infinite-alleles assumption: each mutation instantaneously confers a brand new type, called allele, to its carrier. We are interested in the allele frequency spectrum at time t, i.e., the number A(t) of distinct alleles represented in the population at time t, and more specifically, the numbers A(k,t) of alleles represented by k individuals at time t, k=1,2,...,N_t. We mainly use two classes of tools: coalescent point processes and branching processes counted by random characteristics. We provide explicit formulae for the expectation of A(k,t) in a coalescent point process conditional on population size, which apply to the special case of splitting trees. We separately derive the a.s. limits of A(k,t)/N_t and of A(t)/N_t thanks to random characteristics. Last, we separately compute the expected homozygosity by applying a method characterizing the dynamics of the tree distribution as the origination time of the tree moves back in time, in the spirit of backward Kolmogorov equations.

Review text

The authors deal with a neutral dynamic model of biological diversity, where individuals live and reproduce independently. They provide explicit formulae for the expectation of the numbers of \(A(k,t)\) (alleles represented by \(k\) individuals at time \(t\)) conditional on population size in a coalescent point process, which apply to the special case of splitting trees.

Recommendations

• Splitting trees with neutral mutations at birth
• Moments of the frequency spectrum of a splitting tree with neutral Poissonian mutations
• Birth and death processes with neutral mutations
• Splitting trees with neutral Poissonian mutations. II: Largest and oldest families
• A limit theorem for trees of alleles in branching processes with rare neutral mutations

Cites work

• A critical branching process model for biodiversity
• A limit theorem for trees of alleles in branching processes with rare neutral mutations
• An infinite-alleles version of the simple branching process
• Asymptotic genealogy of a critical branching process
• Asymptotic regimes for the partition into colonies of a branching process with emigration
• Convergence of general branching processes and functionals thereof
• Evolution of resistance and progression to disease during clonal expansion of cancer
• scientific article; zbMATH DE number 3657493 (Why is no real title available?)
• scientific article; zbMATH DE number 53997 (Why is no real title available?)
• scientific article; zbMATH DE number 975598 (Why is no real title available?)
• Limit theorems for sums determined by branching and other exponentially growing processes
• Multitype Bienaymé–Galton–Watson processes escaping extinction
• On the convergence of supercritical general (C-M-J) branching processes
• Size-biased and conditioned random splitting trees
• Splitting trees with neutral Poissonian mutations. II: Largest and oldest families
• The allelic partition for coalescent point processes
• The contour of splitting trees is a Lévy process
• The growth and composition of branching populations
• The structure of the allelic partition of the total population for Galton-Watson processes with neutral mutations

Cited in

(19)

• Mutations on a random binary tree with measured boundary
• Birth and death processes with neutral mutations
• Splitting trees with neutral Poissonian mutations. II: Largest and oldest families
• Approximation of the allelic frequency spectrum in general supercritical branching populations
• Genetic composition of an exponentially growing cell population
• Further properties of a random graph with duplications and deletions
• Mutational pattern of a sample from a critical branching population
• Moments of the frequency spectrum of a splitting tree with neutral Poissonian mutations
• The allelic partition for coalescent point processes
• Central limit theorem for supercritical binary homogeneous Crump-Mode-Jagers processes
• Random ultrametric trees and applications
• scientific article; zbMATH DE number 850224 (Why is no real title available?)
• Splitting Trees Stopped when the First Clock Rings and Vervaat's Transformation
• Asymptotic degree distribution of a duplication-deletion random graph model
• Statistics of branched populations split into different types
• Species abundance distributions in neutral models with immigration or mutation and general lifetimes
• Asymptotics for the site frequency spectrum associated with the genealogy of a birth and death process
• Some properties of the conditioned reconstructed process with Bernoulli sampling
• Splitting trees with neutral mutations at birth

This page was built for publication: Splitting trees with neutral Poissonian mutations. I: Small families

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q765886)