Minimization of intermediate concentrations as a suggested optimality principle for biochemical networks. I: Theoretical analysis

DOI10.1007/BF00160470zbMath0731.92006OpenAlexW2319266936MaRDI QIDQ809002

Reinhart Heinrich, Stefan Schuster

Publication date: 1991

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/bf00160470

zbMATH Keywords

multiobjective optimizationlinear inequalitiesbiochemical reaction networksoptimality principlesconvex conservations relationsminimizing all intermediate concentrationsminimizing the total osmolarity of intermediatesseparation of rate constants

Mathematics Subject Classification ID

Convex programming (90C25) Differential games and control (49N70) Biochemistry, molecular biology (92C40) Pursuit and evasion games (49N75)

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• A theoretical approach to the evolution and structural design of enzymatic networks; linear enzymatic chains, branched pathways and glycolysis of erythrocytes
• Dynamic stability of steady states and static stabilization in unbranched metabolic pathways
• Linear multiobjective programming
• Proper efficiency and the theory of vector maximization
• Convex Analysis

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