Minimization of intermediate concentrations as a suggested optimality principle for biochemical networks. I: Theoretical analysis
DOI10.1007/BF00160470zbMATH Open0731.92006OpenAlexW2319266936MaRDI QIDQ809002FDOQ809002
Reinhart Heinrich, Stefan Schuster
Publication date: 1991
Published in: Journal of Mathematical Biology (Search for Journal in Brave)
Full work available at URL: https://doi.org/10.1007/bf00160470
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biochemical reaction networksmultiobjective optimizationlinear inequalitiesoptimality principlesconvex conservations relationsminimizing all intermediate concentrationsminimizing the total osmolarity of intermediatesseparation of rate constants
Convex programming (90C25) Biochemistry, molecular biology (92C40) Differential games and control (49N70) Pursuit and evasion games (49N75)
Cites Work
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- Optimality in biology and medicine
- A theoretical approach to the evolution and structural design of enzymatic networks; linear enzymatic chains, branched pathways and glycolysis of erythrocytes
- Dynamic stability of steady states and static stabilization in unbranched metabolic pathways
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- Minimization of intermediate concentrations as a suggested optimality principle for biochemical networks. II: Time hierarchy, enzymatic rate laws, and erythrocyte metabolism
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- Convex representation of metabolic networks with Michaelis-Menten kinetics
- Minimization of intermediate concentrations as a suggested optimality principle for biochemical networks. II: Time hierarchy, enzymatic rate laws, and erythrocyte metabolism
- Kinetic and thermodynamic constraints for the structural design of glycolysis
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