Minimization of intermediate concentrations as a suggested optimality principle for biochemical networks. II: Time hierarchy, enzymatic rate laws, and erythrocyte metabolism

DOI10.1007/BF00160471MaRDI QIDQ809004zbMATH OpenWikidataFDO

Authors R. Schuster, Stefan Schuster, Reinhart Heinrich

Publication date 1991

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/BF00160471

zbMATH Keywords

biochemical networksbiochemical reaction systemsenzymatic rate lawserythrocyte human metabolismintermediate concentrationsmultiobjective optimalityquasi-equilibriumtime hierarchy

Mathematics Subject Classification ID

Differential games and control (49N70) Pursuit and evasion games (49N75) Convex programming (90C25) Biochemistry, molecular biology (92C40)

Review text

In part I of the present paper, see the preceding review, Zbl 0731.92006, the multiobjective optimality problem of simultaneously minimizing all intermediate concentrations in biochemical reaction systems was investigated. The proposed method is now applied to a model of a real biochemical system, in order to test the biochemical relevance of the proposed extremum principle. It is proved that one of the four solutions obtained corresponds qualitatively to the real erythrocyte human metabolism. Furthermore, it is shown that for any reaction system, the considered optimality principle implies a distinct time hierarchy in that some reactions are infinitely fast and subsist in quasi-equilibrium. The relationship to the standard method of deriving enzymatic rate laws is also discussed.

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Cites work

• Dynamic stability of steady states and static stabilization in unbranched metabolic pathways
• Enzyme kinetics for a two-step enzymic reaction with comparable initial enzyme-substrate ratios
• scientific article; zbMATH DE number 3591767 (Why is no real title available?)
• scientific article; zbMATH DE number 3619680 (Why is no real title available?)
• Minimization of intermediate concentrations as a suggested optimality principle for biochemical networks. I: Theoretical analysis
• On the pseudo-steady-state approximation and Tikhonov theorem for general enzyme systems

Cited in

(8)

• A theoretical approach to the evolution and structural design of enzymatic networks; linear enzymatic chains, branched pathways and glycolysis of erythrocytes
• Kinetic and thermodynamic principles determing the structural design of ATP-producing systems.
• CMMSE-17: general analytical laws for metabolic pathways
• The markup is the model: reasoning about systems biology models in the semantic web era
• Time Hierarchy in Oscillating Metabolic Systems
• Kinetic and thermodynamic constraints for the structural design of glycolysis
• Model based optimization of biochemical systems using multiple objectives: a comparison of several solution strategies
• Minimization of intermediate concentrations as a suggested optimality principle for biochemical networks. I: Theoretical analysis

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