On the pseudo-steady-state approximation and Tikhonov theorem for general enzyme systems

DOI10.1016/0025-5564(85)90039-2MaRDI QIDQ1068751zbMATH OpenOpenAlexFDO

Authors F. Battelli, Claudio Lazzari

Publication date 1985

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/0025-5564(85)90039-2

zbMATH Keywords

stabilityuniquenesssteady state solutionsadiabatic approximationTikhonov's theorempseudo-steady-state approximationenzymatic networksgeneral closed enzyme systemsligand stoichiometrynonlinear autonomous differential equationsopen enzyme systemsPSSA

Mathematics Subject Classification ID

Asymptotic properties of solutions to ordinary differential equations (34D05) Physiological, cellular and medical topics (92Cxx)

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Cites work

• scientific article; zbMATH DE number 3338381 (Why is no real title available?)
• scientific article; zbMATH DE number 3057045 (Why is no real title available?)
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• ASYMPTOTIC BEHAVIOUR OF SOLUTIONS TO CERTAIN PROBLEMS INVOLVING NON-LINEAR DIFFERENTIAL EQUATIONS CONTAINING A SMALL PARAMETER MULTIPLYING THE HIGHEST DERIVATIVES
• Chemical mechanism structure and the coincidence of the stoichiometric and kinetie subspaces
• Conditions for the application of the steady-state approximation to systems of differential equations
• Singular Perturbations on the Infinite Interval
• Stability in systems with parameter
• The existence of stable limit cycles for enzyme catalyzed reactions with positive feedback

Cited in

(13)

• Boundedness and stable oscillations in two-dimensional enzyme reduced systems
• Behavioral plasticity and virus propagation: the FIV-cat population example
• Asymptotic expansions obtained by a center manifold theorem
• Heineken, Tsuchiya and Aris: ``On the mathematical status of the pseudo-steady state hypothesis. A classic from Volume 1 of \textit{Mathematical Biosciences}
• A general solution for the steady-state kinetics of immobilized enzyme systems
• The total quasi-steady-state approximation for complex enzyme reactions
• Tihonov theory and center manifolds for inhibitory mechanisms in enzyme kinetics
• Graph-based, dynamics-preserving reduction of (bio)chemical systems
• Stability of open pathways
• The quasi-steady-state approximations revisited: timescales, small parameters, singularities, and normal forms in enzyme kinetics
• Remark on an application of a sufficient condition for non-uniqueness to a model in immobilized enzyme systems
• scientific article; zbMATH DE number 3991313 (Why is no real title available?)
• Minimization of intermediate concentrations as a suggested optimality principle for biochemical networks. II: Time hierarchy, enzymatic rate laws, and erythrocyte metabolism

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