Tihonov theory and center manifolds for inhibitory mechanisms in enzyme kinetics

DOI10.1515/caim-2017-0005zbMath1393.34049OpenAlexW2738563313MaRDI QIDQ2364830

Pierluigi Vellucci, A. Milanesi, Alberto Maria Bersani, Alessandro Borri

Publication date: 25 July 2017

Published in: Communications in Applied and Industrial Mathematics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1515/caim-2017-0005

zbMATH Keywords

perturbation theoryenzyme kineticscenter manifoldinhibitionTihonov's theorem

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Qualitative investigation and simulation of ordinary differential equation models (34C60) Invariant manifolds for ordinary differential equations (34C45) Singular perturbations for ordinary differential equations (34E15)

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Tihonov theory and center manifolds for inhibitory mechanisms in enzyme kinetics ⋮ The total quasi-steady-state for multiple alternative substrate reactions ⋮ Uniform Asymptotic Expansions beyond the tQSSA for the Goldbeter--Koshland Switch ⋮ A study case for the analysis of asymptotic expansions beyond the tQSSA for inhibitory mechanisms in enzyme kinetics. ⋮ Singular Perturbation Techniques and Asymptotic Expansions for Some Complex Enzyme Reactions

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