Dynamics of a cell motility model near the sharp interface limit

DOI10.1016/J.JTBI.2020.110420zbMATH Open1455.92015arXiv2006.03017OpenAlexW3033567475WikidataQ98186647 ScholiaQ98186647MaRDI QIDQ827699FDOQ827699

Authors: Nicolas Bolle, Matthew S. Mizuhara 

Publication date: 13 January 2021

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Abstract: Phase-field models have recently had great success in describing the dynamic morphologies and motility of eukaryotic cells. In this work we investigate the minimal phase-field model introduced in [Berlyand, Potomkin, Rybalko (2017)]. Rigorous analysis of its sharp interface limit dynamics was completed in [Mizuhara, Berlyand, Rybalko, Zhang (2016); Mizuhara, Zhang (2019)], where it was observed that persistent cell motion was not stable. In this work we numerically study the pre-limiting phase-field model near the sharp interface limit, to better understand this lack of persistent motion. We find that immobile, persistent, and rotating states are all exhibited in this minimal model, and investigate the loss of persistent motion in the sharp interface limit. In addition we study cell speed as a function of biophysical parameters.

Full work available at URL: https://arxiv.org/abs/2006.03017

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zbMATH Keywords

traveling wavephase-fieldkeratocyte motionrotating cell

Mathematics Subject Classification ID

PDEs in connection with biology, chemistry and other natural sciences (35Q92) Cell movement (chemotaxis, etc.) (92C17)

Cites Work

• Sharp interface limit in a phase field model of cell motility
• On an evolution equation in a cell motility model
• Mathematics of cell motility: Have we got its number?
• Mathematical modeling of myosin induced bistability of lamellipodial fragments
• Intracellular fluid mechanics: coupling cytoplasmic flow with active cytoskeletal gel
• Uniqueness and traveling waves in a cell motility model

Cited In (10)

• A simple model of keratocyte membrane dynamics: the case of motionless living cell
• A cellular Potts energy-based approach to analyse the influence of the surface topography on single cell motility
• Moving boundary problem for a one-dimensional crawling nematode sperm cell model
• A Cahn-Hilliard model for cell motility
• Cell polarity and movement with reaction-diffusion and moving boundary: rigorous model analysis and robust simulations
• Phase-field model of cell motility: traveling waves and sharp interface limit
• A Novel Derivation of Rigorous Macroscopic Limits from a Micro-Meso Description of Signal-Triggered Cell Migration in Fibrous Environments
• Phase field model for cell spreading dynamics
• Excitable dynamics in a molecularly-explicit model of cell motility: mixed-mode oscillations and beyond
• Sharp interface limit in a phase field model of cell motility

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