Stability and bifurcations in a model of antigenic variation in malaria
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Publication:843281
DOI10.1007/S00285-008-0204-0zbMATH Open1204.92045arXiv1201.4591OpenAlexW3106528872WikidataQ47874102 ScholiaQ47874102MaRDI QIDQ843281FDOQ843281
Authors: K. B. Blyuss, Sunetra Gupta 
Publication date: 12 October 2009
Published in: Journal of Mathematical Biology (Search for Journal in Brave)
Abstract: We examine the properties of a recently proposed model for antigenic variation in malaria which incorporates multiple epitopes and both long-lasting and transient immune responses. We show that in the case of a vanishing decay rate for the long-lasting immune response, the system exhibits the so-called "bifurcations without parameters" due to the existence of a hypersurface of equilibria in the phase space. When the decay rate of the long-lasting immune response is different from zero, the hypersurface of equilibria degenerates, and a multitude of other steady states are born, many of which are related by a permutation symmetry of the system. The robustness of the fully symmetric state of the system was investigated by means of numerical computation of transverse Lyapunov exponents. The results of this exercise indicate that for a vanishing decay of long-lasting immune response, the fully symmetric state is not robust in the substantial part of the parameter space, and instead all variants develop their own temporal dynamics contributing to the overall time evolution. At the same time, if the decay rate of the long-lasting immune response is increased, the fully symmetric state can become robust provided the growth rate of the long-lasting immune response is rapid.
Full work available at URL: https://arxiv.org/abs/1201.4591
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Cited In (18)
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- Equivariant Hopf bifurcation in a time-delayed ring of antigenic variants
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- Stochastic stability of Markovian jumping genetic regulatory networks with mixed time delays
- Oscillations in an intra-host model of Plasmodium falciparum malaria due to cross-reactive immune response
- Title not available (Why is that?)
- Mathematical analysis of a general class of ordinary differential equations coming from within-hosts models of malaria with immune effectors
- Bifurcations and multistability in a model of cytokine-mediated autoimmunity
- Symmetry breaking in a model of antigenic variation with immune delay
- The effects of symmetry on the dynamics of antigenic variation
- Synchronous versus asynchronous oscillations for antigenically varying \textit{Plasmodium falciparum} with host immune response
- Global properties of nested network model with application to multi-epitope HIV/CTL dynamics
- Analysis of symmetries in models of multi-strain infections
- Chimera states in multi-strain epidemic models with temporary immunity
- On the stability and Hopf bifurcation of the non-zero uniform endemic equilibrium of a time-delayed malaria model
- Synchrony-breaking Hopf bifurcation in a model of antigenic variation
- Instability of disease-free equilibrium in a model of malaria with immune delay
- Capturing the dynamics of pathogens with many strains
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