The effects of symmetry on the dynamics of antigenic variation
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Publication:1937883
DOI10.1007/S00285-012-0508-YzbMATH Open1256.92024arXiv1202.4290OpenAlexW3101738286WikidataQ48000791 ScholiaQ48000791MaRDI QIDQ1937883FDOQ1937883
Authors: K. B. Blyuss 
Publication date: 1 February 2013
Published in: Journal of Mathematical Biology (Search for Journal in Brave)
Abstract: In the studies of dynamics of pathogens and their interactions with a host immune system, an important role is played by the structure of antigenic variants associated with a pathogen. Using the example of a model of antigenic variation in malaria, we show how many of the observed dynamical regimes can be explained in terms of the symmetry of interactions between different antigenic variants. The results of this analysis are quite generic, and have wider implications for understanding the dynamics of immune escape of other parasites, as well as for the dynamics of multi-strain diseases.
Full work available at URL: https://arxiv.org/abs/1202.4290
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Cited In (13)
- Codimension one and two bifurcations in a symmetrical ring network with delay
- Equivariant Hopf bifurcation in a time-delayed ring of antigenic variants
- On the evolution of genetic incompatibility systems. IV: Modification of response to an existing antigen polymorphism under partial selfing
- A stochastic microscopic model for the dynamics of antigenic variation
- Symmetry, Hopf bifurcation, and the emergence of cluster solutions in time delayed neural networks
- An age-structured multi-strain epidemic model for antigenically diverse infectious diseases: a multi-locus framework
- Analysis of symmetries in models of multi-strain infections
- Chimera states in multi-strain epidemic models with temporary immunity
- On the stability and Hopf bifurcation of the non-zero uniform endemic equilibrium of a time-delayed malaria model
- Mathematical analysis of a multiple strain, multi-locus-allele system for antigenically variable infectious diseases revisited
- Instability of disease-free equilibrium in a model of malaria with immune delay
- From within host dynamics to the epidemiology of infectious disease: scientific overview and challenges
- Capturing the dynamics of pathogens with many strains
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