Immune response to a malaria infection: properties of a mathematical model

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Publication:3520264

DOI10.1080/17513750701769865zbMATH Open1140.92013arXiv0707.4497OpenAlexW2144770418WikidataQ38033581 ScholiaQ38033581MaRDI QIDQ3520264FDOQ3520264


Authors: Patrick De Leenheer, Sergei S. Pilyugin Edit this on Wikidata


Publication date: 15 August 2008

Published in: Journal of Biological Dynamics (Search for Journal in Brave)

Abstract: We establish some properties of a within host mathematical model of malaria proposed by Recker et al which includes the role of the immune system during the infection. The model accounts for the antigenic variation exhibited by the malaria parasite (P. falciparum). We show that the model can exhibit a wide variety of dynamical behaviors. We provide criteria for global stability, competitive exclusion, and persistence. We also demonstrate that the disease equilibrium can be destabilized by non-symmetric cross-reactive responses.


Full work available at URL: https://arxiv.org/abs/0707.4497




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