Searching for a source of difference in graphical models

DOI10.1016/J.JMVA.2022.104973zbMATH Open1493.62363arXiv1811.02503OpenAlexW4213031389MaRDI QIDQ88388FDOQ88388

Authors: Vera Djordjilovi'C, Monica Chiogna, Vera Djordjilović, Monica Chiogna 

Publication date: July 2022

Published in: Journal of Multivariate Analysis (Search for Journal in Brave)

Abstract: In this work, we look at a two-sample problem within the framework of Gaussian graphical models. When the global hypothesis of equality of two distributions is rejected, the interest is usually in localizing the source of difference. Motivated by the idea that diseases can be seen as system perturbations, and by the need to distinguish between the origin of perturbation and components affected by the perturbation, we introduce the concept of a minimal seed set, and its graphical counterpart a graphical seed set. They intuitively consist of variables driving the difference between the two conditions. We propose a simple testing procedure, linear in the number of nodes, to estimate the graphical seed set from data, and study its finite sample behavior with a stimulation study. We illustrate our approach in the context of gene set analysis by means of a publicly available gene expression dataset.

Full work available at URL: https://arxiv.org/abs/1811.02503

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zbMATH Keywords

decomposable graphical modelsdecompositionGaussian graphical modelsgraphical log-linear modelsstrong meta Markov modelstwo sample problem

Mathematics Subject Classification ID

Parametric hypothesis testing (62F03) Probabilistic graphical models (62H22)

Cites Work

• Title not available (Why is that?)
• Hyper Markov laws in the statistical analysis of decomposable graphical models
• Uniform consistency in causal inference
• Information and exponential families in statistical theory
• Direct estimation of differential networks
• Decomposition of maximum likelihood in mixed graphical interaction models
• On the distribution of quadratic forms in normal random variables
• Title not available (Why is that?)
• Graphical models for skew‐normal variates
• Testing differential networks with applications to the detection of gene-gene interactions

Cited In (4)

• A Bartlett-type correction for likelihood ratio tests with application to testing equality of Gaussian graphical models
• Searching for the \(m\) best solutions in graphical models
• SourceSet
• Locally associated graphical models and mixed convex exponential families

Uses Software

• R
• gRbase
• limma
• KEGG
• graphite
• GlobalAncova

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