Assessing the association between trends in a biomarker and risk of event with an application in pediatric HIV/AIDS
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Abstract: We present a new joint longitudinal and survival model aimed at estimating the association between the risk of an event and the change in and history of a biomarker that is repeatedly measured over time. We use cubic B-splines models for the longitudinal component that lend themselves to straight-forward formulations of the slope and integral of the trajectory of the biomarker. The model is applied to data collected in a long term follow-up study of HIV infected infants in Uganda. Estimation is carried out using MCMC methods. We also explore using the deviance information criteria, the conditional predictive ordinate and ROC curves for model selection and evaluation.
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Cited in
(12)- Joint models with multiple longitudinal outcomes and a time-to-event outcome: a corrected two-stage approach
- Quantile regression-based Bayesian joint modeling analysis of longitudinal-survival data, with application to an AIDS cohort study
- Assessing importance of biomarkers: A Bayesian joint modelling approach of longitudinal and survival data with semi-competing risks
- A Flexible B‐Spline Model for Multiple Longitudinal Biomarkers and Survival
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