Assessing the association between trends in a biomarker and risk of event with an application in pediatric HIV/AIDS

DOI10.1214/09-AOAS251zbMATH Open1196.62136arXiv0910.1667OpenAlexW2070961563WikidataQ38871928 ScholiaQ38871928MaRDI QIDQ985033FDOQ985033

Authors: Elizabeth R. Brown 

Publication date: 20 July 2010

Published in: The Annals of Applied Statistics (Search for Journal in Brave)

Abstract: We present a new joint longitudinal and survival model aimed at estimating the association between the risk of an event and the change in and history of a biomarker that is repeatedly measured over time. We use cubic B-splines models for the longitudinal component that lend themselves to straight-forward formulations of the slope and integral of the trajectory of the biomarker. The model is applied to data collected in a long term follow-up study of HIV infected infants in Uganda. Estimation is carried out using MCMC methods. We also explore using the deviance information criteria, the conditional predictive ordinate and ROC curves for model selection and evaluation.

Full work available at URL: https://arxiv.org/abs/0910.1667

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zbMATH Keywords

HIV/AIDSdisease progressionbiomarker changejoint longitudinal and survival modelsmother-to-child transmission

Mathematics Subject Classification ID

Estimation in survival analysis and censored data (62N02) Applications of statistics to biology and medical sciences; meta analysis (62P10) Numerical analysis or methods applied to Markov chains (65C40) Medical applications (general) (92C50) Numerical computation using splines (65D07)

Cites Work

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Cited In (8)

• Bayesian inference and dynamic prediction for multivariate longitudinal and survival data
• Modeling the underlying biological processes in Alzheimer's disease using a multivariate competing risk joint model
• Quantile regression-based Bayesian joint modeling analysis of longitudinal-survival data, with application to an AIDS cohort study
• Joint models with multiple longitudinal outcomes and a time-to-event outcome: a corrected two-stage approach
• Assessing importance of biomarkers: A Bayesian joint modelling approach of longitudinal and survival data with semi-competing risks
• Multivariate functional mixed model with MRI data: an application to Alzheimer's disease
• Shared decision making of burdensome surveillance tests using personalized schedules and their burden and benefit
• A Flexible B‐Spline Model for Multiple Longitudinal Biomarkers and Survival

Uses Software

• R
• CODA

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