Modeling long-term longitudinal HIV dynamics with application to an AIDS clinical study

DOI10.1214/08-AOAS192zbMath1169.92026arXiv0901.3806OpenAlexW3099393500MaRDI QIDQ999668

Yangxin Huang, Tao Lü

Publication date: 10 February 2009

Published in: The Annals of Applied Statistics (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/0901.3806

zbMATH Keywords

longitudinal datatime-varying drug efficacyantiretroviral drug therapyBayesian nonlinear mixed-effects modelslong-term HIV dynamics

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Bayesian inference (62F15) Dynamical systems in biology (37N25) Medical applications (general) (92C50)

Related Items (4)

Dynamics of the HIV infection under antiretroviral therapy: a cellular automata approach ⋮ Cellular automata approach for the dynamics of HIV infection under antiretroviral therapies: the role of the virus diffusion ⋮ Estimating mixed-effects differential equation models ⋮ Time-varying pharmacodynamics in a simple non-integer HIV infection model

Uses Software

• R
• S-PLUS
• IMSL Numerical Libraries
• SAS
• MEMSS
• SAS/STAT

Cites Work

• HIV-1 infection and low steady state viral loads
• Identifiability results on some constrained compartmental systems
• Modeling HIV dynamics and antiviral response with consideration of time-varying drug exposures, adherence and phenotypic sensitivity
• Relationships between antiviral treatment effects and biphasic viral decay rates in modeling HIV dynamics
• Models and estimation methods for clinical HIV-1 data
• The Bayesian Analysis of Population Pharmacokinetic Models
• A Bayesian approach for estimating antiviral efficacy in HIV dynamic models
• Sampling-Based Approaches to Calculating Marginal Densities
• Stochastic Relaxation, Gibbs Distributions, and the Bayesian Restoration of Images
• Mathematical Analysis of HIV-1 Dynamics in Vivo
• A Two-Step Approach to Measurement Error in Time-Dependent Covariates in Nonlinear Mixed-Effects Models, With Application to IGF-I Pharmacokinetics
• Assessing antiviral potency of anti-HIV therapies in vivo by comparing viral decay rates in viral dynamic models
• A Joint Model for Nonlinear Mixed-Effects Models With Censoring and Covariates Measured With Error, With Application to AIDS Studies
• Mixed-Effects Models in S and S-PLUS
• Population HIV‐1 Dynamics In Vivo: Applicable Models and Inferential Tools for Virological Data from AIDS Clinical Trials
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