Random collision model for random genetic drift and stochastic difference equation

DOI10.1007/BF02481975MaRDI QIDQ1057792zbMATH OpenOpenAlexFDO

Authors Yoshiaki Itoh

Publication date 1984

Published in Annals of the Institute of Statistical Mathematics (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/bf02481975

zbMATH Keywords

approximately asymptotic time-average heterozigosityfitness schemesMonte Carlo simulationmutationone-locus multiallelic genetic modeloverdominant selectionpopulation geneticsrandom collision modelrandom genetic driftstochastic difference equationsWright-Kimura infinite allele model

Mathematics Subject Classification ID

Stochastic analysis (60H99) Probabilistic models, generic numerical methods in probability and statistics (65C20) Probabilistic methods, stochastic differential equations (65C99) Genetics and epigenetics (92D10)

Review text

The author studies by Monte Carlo simulation a one-locus multiallelic genetic model contemplating random genetic drift, mutation (Wright-Kimura infinite allele model), and overdominant selection (all heterozygotes have fitnesss 1-s, with \(s>0\), and all homozygotes have fitness 1). It can be generalized to other fitness schemes. Rather than taking the approach of \textit{T. Maruyama} and \textit{M. Nei} [Genetic variability maintained by mutation and overdominant selection in finite populations. Genetics 98, 441-459 (1982)] of solving analytically (case \(s=0)\) or numerically a stochastic difference equation, the author uses simulated direct sampling based on an ingenious random collision model. To project from time t to time \(t+\Delta t\), collisions between alleles occur at a rate proportional to \(\Delta\) t for each allele. For random genetic drift, collisions of two alleles are considered [to form the newborn zygotes that replace the dead ones]. For selection, collision of four alleles are required (corresponding to the choice of two mates, each one with two alleles). There are other technical details of some importance concerning the decomposition of the variance-covariance matrix. The numerical results obtained for the approximately asymptotic time-average heterozigosity in a variety of situations are very similar to those obtained by Maruyama and Nei using stochastic difference equations.

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Cites work

• An H-theorem for a system of competing species
• scientific article; zbMATH DE number 3148873 (Why is no real title available?)
• scientific article; zbMATH DE number 3657493 (Why is no real title available?)
• Non-associative algebra and Lotka-Volterra equation with ternary interaction
• On a ruin problem with interaction
• Random collision models in oriented graphs
• Stochastic theory of population genetics

Cited in

(1)

• Comparison and content of the Wright-Fisher model of random genetic drift, the diffusion approximation, and an intermediate model

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