Searching for a source of difference in graphical models

DOI10.1016/J.JMVA.2022.104973MaRDI QIDQ88388zbMATH OpenOpenAlexFDO

Authors Vera Djordjilovi'C, Monica Chiogna, Vera Djordjilović, Monica Chiogna

Publication date July 2022

Published in Journal of Multivariate Analysis (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1811.02503

zbMATH Keywords

decomposable graphical modelsdecompositionGaussian graphical modelsgraphical log-linear modelsstrong meta Markov modelstwo sample problem

Mathematics Subject Classification ID

Parametric hypothesis testing (62F03) Probabilistic graphical models (62H22)

Abstract: In this work, we look at a two-sample problem within the framework of Gaussian graphical models. When the global hypothesis of equality of two distributions is rejected, the interest is usually in localizing the source of difference. Motivated by the idea that diseases can be seen as system perturbations, and by the need to distinguish between the origin of perturbation and components affected by the perturbation, we introduce the concept of a minimal seed set, and its graphical counterpart a graphical seed set. They intuitively consist of variables driving the difference between the two conditions. We propose a simple testing procedure, linear in the number of nodes, to estimate the graphical seed set from data, and study its finite sample behavior with a stimulation study. We illustrate our approach in the context of gene set analysis by means of a publicly available gene expression dataset.

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Cites work

• scientific article; zbMATH DE number 1134987 (Why is no real title available?)
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Cited in

(4)

• A Bartlett-type correction for likelihood ratio tests with application to testing equality of Gaussian graphical models
• Searching for the \(m\) best solutions in graphical models
• SourceSet
• Locally associated graphical models and mixed convex exponential families

Describes a project that uses

Uses Software

• GlobalAncova
• graphite
• KEGG
• limma
• gRbase
• R

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