DoseFinding

swMATH8194CRANDoseFindingMaRDI QIDQ20204FDOQ20204

Planning and Analyzing Dose Finding Experiments

Jose Pinheiro, Bjoern Bornkamp, Frank Bretz, Marius Thomas, Ludger Sandig

Last update: 2 November 2023

Copyright license: GNU General Public License, version 3.0

Software version identifier: 1.0-3, 1.0-4, 0.1-1, 0.1-2, 0.1-3, 0.1, 0.2-1, 0.2-2, 0.2-3, 0.3-1, 0.4-1, 0.4-2, 0.4-3, 0.5-1, 0.5-2, 0.5-3, 0.5-4, 0.5-5, 0.5-6, 0.5-7, 0.6-1, 0.6-2, 0.6-3, 0.9-1, 0.9-3, 0.9-4, 0.9-5, 0.9-6, 0.9-7, 0.9-8, 0.9-9, 0.9-10, 0.9-11, 0.9-12, 0.9-13, 0.9-14, 0.9-15, 0.9-16, 0.9-17, 1.0-1, 1.0-2, 1.0-5, 1.1-1

Source code repository: https://github.com/cran/DoseFinding

Description

The DoseFinding package provides functions for the design and analysis of dose-finding experiments (with focus on pharmaceutical Phase II clinical trials). It provides functions for: multiple contrast tests, fitting non-linear dose-response models (using Bayesian and non-Bayesian estimation), calculating optimal designs and an implementation of the MCPMod methodology (Pinheiro et al. (2014) <doi:10.1002/sim.6052>).

Cites work

• Model-based dose finding under model uncertainty using general parametric models

Cited In (19)

• BayesianMCPMod
• Testing effect of a drug using multiple nested models for the dose–response
• The effects of adaptation on maximum likelihood inference for nonlinear models with normal errors
• Functional Uniform Priors for Nonlinear Modeling
• Practical considerations for using functional uniform prior distributions for dose-response estimation in clinical trials
• Unimodal regression using Bernstein–Schoenberg splines and penalties
• uniReg
• Title not available (Why is that?)
• dosedesignR
• Title not available (Why is that?)
• MCPModBC
• Response-adaptive dose-finding under model uncertainty
• clinDR
• MCPModGeneral
• TestingSimilarity
• clustDRM
• Equivalence of Regression Curves
• LRcontrast
• Book Reviews

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