topologyGSA
swMATH15178CRANtopologyGSAMaRDI QIDQ27071FDOQ27071
Gene Set Analysis Exploiting Pathway Topology
Last update: 25 September 2023
Copyright license: GNU General Public License, version 3.0
Software version identifier: 1.4.7, 1.0.2, 1.0.3, 1.0, 1.1.0, 1.2.0, 1.2.1, 1.4.0, 1.4.1, 1.4.2, 1.4.3, 1.4.4, 1.4.5, 1.4.6, 1.5.0
Source code repository: https://github.com/cran/topologyGSA
Using Gaussian graphical models we propose a novel approach to perform pathway analysis using gene expression. Given the structure of a graph (a pathway) we introduce two statistical tests to compare the mean and the concentration matrices between two groups. Specifically, these tests can be performed on the graph and on its connected components (cliques). The package is based on the method described in Massa M.S., Chiogna M., Romualdi C. (2010) <doi:10.1186/1752-0509-4-121>.
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