Statistics of genome architecture

DOI10.1016/J.PHYSLETA.2013.10.021MaRDI QIDQ397770zbMATH OpenOpenAlexFDO

Authors Vladimir R. Chechetkin

Publication date 12 August 2014

Published in Physics Letters. A (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1310.3459

zbMATH Keywords

distribution of lengthsevolution of architecturegenome trackshierarchical foldingstatistical analysis

Mathematics Subject Classification ID

Probability distributions: general theory (60E05) Applications of statistics to biology and medical sciences; meta analysis (62P10) Genetics and epigenetics (92D10)

Abstract: The main statistical distributions applicable to the analysis of genome architecture and genome tracks are briefly discussed and critically assessed. Although the observed features in distributions of element lengths can be equally well fitted by the different statistical approximations, the interpretation of observed regularities may strongly depend on the chosen scheme. We discuss the possible evolution scenarios and describe the main characteristics obtained with different distributions. The expression for the assessment of levels in hierarchical chromatin folding is derived and the quantitative measure of genome architecture inhomogeneity is suggested. This theory provides the ground for the regular statistical study of genome architecture and genome tracks.

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Cites work

• An overview of recent developments in genomics and associated statistical methods
• scientific article; zbMATH DE number 3349081 (Why is no real title available?)
• Spectral sum rules and search for periodicities in DNA sequences

Cited in

(4)

• Statistical dynamics of clustering in the genome structure
• Large-scale chromosome folding versus genomic DNA sequences: a discrete double Fourier transform technique
• Long- and short-range correlations in genome organization
• Scale invariant correlations between genes and SNPs on human chromosome 1 reveal potential evolutionary mechanisms

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