Stokes efficiency of molecular motor-cargo systems

DOI10.1155/2008/241736MaRDI QIDQ938384zbMATH OpenOpenAlexWikidataFDO

Authors Hongyun Wang, Hong Zhou

Publication date 19 August 2008

Published in Abstract and Applied Analysis (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://eudml.org/doc/54379

Mathematics Subject Classification ID

Applications of Markov chains and discrete-time Markov processes on general state spaces (social mobility, learning theory, industrial processes, etc.) (60J20) Incompressible viscous fluids (76D99) Biochemistry, molecular biology (92C40) Classical flows, reactions, etc. in chemistry (92E20) Chemistry (92E99)

Review text

Summary: A molecular motor utilizes chemical free energy to generate a unidirectional motion through a viscous fluid. In many experimental and biological settings, a molecular motor is elastically linked to a cargo. The stochastic motion of a molecular motor-cargo system is governed by a set of Langevin equations, each corresponding to an individual chemical occupancy state. The change of the chemical occupancy state is modeled by a continuous time discrete space Markov process. The probability density of a motor-cargo system is governed by a two-dimensional Fokker-Planck equation. The operation of a molecular motor is dominated by high viscous friction and large thermal fluctuations from the surrounding fluid. The instantaneous velocity of a molecular motor is highly stochastic: the past velocity is quickly damped by the viscous friction and the new velocity is quickly excited by bombardments of surrounding fluid molecules. Thus, the theory for macroscopic motors should not be applied directly to molecular motors without close examination. In particular, a molecular motor behaves differently working against a viscous drag than working against a conservative force. The Stokes efficiency was introduced to measure how efficiently a motor uses chemical free energy to drive against a viscous drag. For a motor without cargo, it was proved that the Stokes efficiency is bounded by 100\%. Here, we present a proof for the general motor-cargo system.

Recommendations

• Stokes efficiency of molecular motors with inertia
• The entropy and efficiency of a molecular motor model
• The efficiency of molecular motors
• Molecular motors, Brownian ratchets, and reflected diffusions
• Effective behavior of cooperative and nonidentical molecular motors

Cites work

• scientific article; zbMATH DE number 3119871 (Why is no real title available?)
• scientific article; zbMATH DE number 2027759 (Why is no real title available?)
• scientific article; zbMATH DE number 6818310 (Why is no real title available?)
• Statistical physics II. Nonequilibrium statistical mechanics.
• The Fokker-Planck equation. Methods of solution and applications.

Cited in

(2)

• Stokes efficiency of molecular motors with inertia
• Efficiency bounds of molecular motors under a trade-off figure of merit

This page was built for publication: Stokes efficiency of molecular motor-cargo systems

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q938384)