The variance of pairwise nucleotide differences in two populations with migration

DOI10.1006/TPBI.1996.0002MaRDI QIDQ1914176zbMATH OpenOpenAlexWikidataFDO

Authors John Wakeley

Publication date 6 October 1998

Published in Theoretical Population Biology (Search for Journal in Brave)

Full work available at URL https://semanticscholar.org/paper/630e86e19ff0d2d84b59de5e55ece3a582f3cfb4

zbMATH Keywords

migrationmultiple DNA sequencespopulation geneticssubdivisionvariance of pairwise nucleotide differences

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Problems related to evolution (92D15) Protein sequences, DNA sequences (92D20)

Review text

Understanding the demographic history of natural populations is of fundamental significance in population genetics. The multitudes of DNA sequence data currently being collected offer the hope of accurately quantifying important genetic and demographic parameters. Of particular interest are samples of multiple DNA sequences from single species, e.g., \textit{S. V. Edwards} [Proc. R. Soc. Lond., Ser. B 252, 177-185 (1993)], since the numbers of nucleotide differences and the genealogies of sequences contain information about population genetic history. This paper is concerned with the effects that population subdivision and migration have on the variance of pairwise nucleotide differences. The model of population subdivision considered here is a two-population version of the finite-island model [see \textit{M. Kimura} and \textit{G. H. Weiss}, Genetics 49, 561-576 (1964); \textit{T. Maruyama}, Theor. Popul. Biol. 1, 273-306 (1970; Zbl 0255.92006)]. While this model is an over-simplification of the demography of most natural populations, it does provide a starting-point from which we can draw initial conclusions.

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Cited in

(4)

• Distinguishing migration from isolation using the variance of pairwise differences
• The effect of migration during the divergence
• Two Variance Results in Population Genetics Theory
• Population differentiation and migration: Coalescence times in a two-sex island model for autosomal and X-linked loci

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