Toward Modelling and Analysis of Transient and Sustained Behaviour of Signalling Pathways

DOI10.1007/978-3-319-47151-8_4MaRDI QIDQ5204371zbMATH OpenOpenAlexFDO

Authors Matej Hajnal, D. Šafránek, Martin Demko, Samuel Pastva, Pavel Krejč{í }, Luboš Brim

Publication date 4 December 2019

Published in Hybrid Systems Biology (Search for Journal in Brave)

Full work available at URL https://rd.springer.com/content/pdf/10.1007%2F978-3-319-47151-8_4.pdf

zbMATH Keywords

cellular information processinggene expressionparametrised ODE modelssignalling pathways

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Systems biology, networks (92C42) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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Cited in

(17)

• Thresholds in transient dynamics of signal transduction pathways
• Parameter space exploration within dynamic simulations of signaling networks
• No-oscillation theorem for the transient dynamics of the linear signal transduction pathway and beyond
• Dynamics and stability of a three-dimensional model of cell signal transduction
• Model based analysis of signaling pathways
• Tests for Cycling in a Signalling Pathway
• A Reversible Process Calculus and the Modelling of the ERK Signalling Pathway
• A generic model for open signaling cascades with forward activation
• A Model of the Signal Transduction Process under a Delay
• MODELING THE NONLINEAR DYNAMICS OF CELLULAR SIGNAL TRANSDUCTION
• The meaning of sensitivity functions in signaling pathways analysis
• Modeling Protein Expression and Protein Signaling Pathways
• Integration of sensitivity and bifurcation analysis to detect critical processes in a model combining signalling and cell population dynamics
• Effective parameters determining the information flow in hierarchical biological systems
• Modular modelling of signalling pathways and their cross-talk
• A mass action model of a fibroblast growth factor signaling pathway and its simplification
• Relating continuous and discrete PEPA models of signalling pathways

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