Two-scale large deviations for chemical reaction kinetics through second quantization path integral

DOI10.1088/1751-8113/49/13/135204MaRDI QIDQ3186361zbMATH OpenOpenAlexFDO

Authors Feng Lin, Tiejun Li

Publication date 9 August 2016

Published in Journal of Physics A: Mathematical and Theoretical (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1508.06907

zbMATH Keywords

chemical Langevin approximationmean-field limitMichaelis-Mentensecond quantization path integralsingular perturbationtwo-scale large deviations

Mathematics Subject Classification ID

Singular perturbations in context of PDEs (35B25) Large deviations (60F10) Chemical kinetics in thermodynamics and heat transfer (80A30) Path integrals in quantum mechanics (81S40) Quantization in field theory; cohomological methods (81T70) Many-body theory; quantum Hall effect (81V70) Stochastic methods (Fokker-Planck, Langevin, etc.) applied to problems in time-dependent statistical mechanics (82C31) Protein sequences, DNA sequences (92D20)

Abstract: Motivated by the study of rare events for a typical genetic switching model in systems biology, in this paper we aim to establish the general two-scale large deviations for chemical reaction systems. We build a formal approach to explicitly obtain the large deviation rate functionals for the considered two-scale processes based upon the second-quantization path integral technique. We get three important types of large deviation results when the underlying two times scales are in three different regimes. This is realized by singular perturbation analysis to the rate functionals obtained by path integral. We find that the three regimes possess the same deterministic mean-field limit but completely different chemical Langevin approximations. The obtained results are natural extensions of the classical large volume limit for chemical reactions. We also discuss its implication on the single-molecule Michaelis-Menten kinetics. Our framework and results can be applied to understand general multi-scale systems including diffusion processes.

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