Large deviations for two-scale chemical kinetic processes

DOI10.4310/CMS.2017.V15.N1.A6MaRDI QIDQ510233zbMATH OpenOpenAlexFDO

Authors Feng Lin, Tiejun Li

Publication date 17 February 2017

Published in Communications in Mathematical Sciences (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1504.03781

zbMATH Keywords

rare eventschemical kinetic processesgenetic switchingtwo-scale large deviations

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Large deviations (60F10) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Abstract: We formulate the large deviations for a class of two scale chemical kinetic processes motivated from biological applications. The result is successfully applied to treat a genetic switching model with positive feedbacks. The corresponding Hamiltonian is convex with respect to the momentum variable as a by-product of the large deviation theory. This property ensures its superiority in the rare event simulations compared with the result obtained by formal WKB asymptotics. The result is of general interest to understand the large deviations for multiscale problems.

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• Two-scale large deviations for chemical reaction kinetics through second quantization path integral
• Large deviations of jump process fluxes
• Structure preserving schemes for Fokker-Planck equations of irreversible processes
• Large deviations of a forced velocity-jump process with a Hamilton-Jacobi approach
• Detailed balance, local detailed balance, and global potential for stochastic chemical reaction networks
• Large-deviation principles of switching Markov processes via Hamilton-Jacobi equations
• Large deviations for the two-time-scale stochastic convective Brinkman-Forchheimer equations
• On the geometry of chemical reaction networks: Lyapunov function and large deviations
• Large deviation for two-time-scale stochastic Burgers equation
• Large deviations of Markov chains with multiple time-scales
• Large deviations for Gaussian diffusions with delay

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