A systematic survey of the response of a model NF-\(\kappa\)B signalling pathway to \(\mathrm{TNF}\alpha\) stimulation

DOI10.1016/J.JTBI.2011.12.014zbMath1336.92029OpenAlexW2044305827WikidataQ42157491 ScholiaQ42157491MaRDI QIDQ285222

Douglas B. Kell, Mark R. Muldoon, Pawel Paszek, Caroline A. Horton, Hong Yue, David S. Broomhead, Yunjiao Wang, Michael R. H. White

Publication date: 19 May 2016

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2011.12.014

zbMATH Keywords

oscillationsbifurcation analysisNF-\(\kappa\)B signalling pathwayparameter sensitivity

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Cell biology (92C37)

Related Items (4)

A simple model of NF-\(\kappa\)B dynamics reproduces experimental observations ⋮ Critical roles of I\(\kappa\)B\(\alpha\) and RelA phosphorylation in transitional oscillation in NF-\(\kappa\)B signaling module ⋮ Mathematical models for immunology: current state of the art and future research directions ⋮ A method of `speed coefficients' for biochemical model reduction applied to the NF-\(\kappa\)B system

Uses Software

• AUTO2000
• XPPAUT

Cites Work

• Mathematical model of NF-\( \kappa\)B regulatory module
• Simulating, Analyzing, and Animating Dynamical Systems

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