A simple model of NF-\(\kappa\)B dynamics reproduces experimental observations

DOI10.1016/j.jtbi.2014.01.015zbMath1412.92141OpenAlexW2092829569WikidataQ51121551 ScholiaQ51121551MaRDI QIDQ2632604

Samuel Zambrano, Alessandra Agresti, Marco E. Bianchi

Publication date: 15 May 2019

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2014.01.015

zbMATH Keywords

oscillationsmathematical modelingsignalling pathwaystranscription factor dynamics

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Biochemistry, molecular biology (92C40)

Cites Work

• A systematic survey of the response of a model NF-\(\kappa\)B signalling pathway to \(\mathrm{TNF}\alpha\) stimulation
• Nonlinear oscillations, dynamical systems, and bifurcations of vector fields
• Markovian modelling of gene product synthesis
• Mathematical model of NF-\( \kappa\)B regulatory module
• Necessary Conditions for Multistationarity and Stable Periodicity
• Modeling and analysis of mass-action kinetics

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