A simple model of NF-B dynamics reproduces experimental observations

DOI10.1016/J.JTBI.2014.01.015MaRDI QIDQ2632604zbMATH OpenOpenAlexWikidataFDO

Authors Samuel Zambrano, Marco Bianchi, Alessandra Agresti

Publication date 15 May 2019

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2014.01.015

zbMATH Keywords

mathematical modelingoscillationssignalling pathwaystranscription factor dynamics

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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Cites work

• A systematic survey of the response of a model NF-\(\kappa\)B signalling pathway to \(\mathrm{TNF}\alpha\) stimulation
• Markovian modelling of gene product synthesis
• Mathematical model of NF-\( \kappa\)B regulatory module
• Modeling and analysis of mass-action kinetics
• Necessary conditions for multistationarity and stable periodicity
• Nonlinear oscillations, dynamical systems, and bifurcations of vector fields

Cited in

(12)

• On the effect of circadian oscillations on biochemical cell signaling by NF- B
• A systematic survey of the response of a model NF-\(\kappa\)B signalling pathway to \(\mathrm{TNF}\alpha\) stimulation
• \textit{NF}-\(\kappa B\) oscillations and cell-to-cell variability
• Spatio-temporal modelling of the NF-B intracellular signalling pathway: the roles of diffusion, active transport, and cell geometry
• The dynamics of NF-\(\kappa\)B pathway regulated by circadian clock
• Planning identification experiments for cell signaling pathways: an NF\(\kappa \)B case study
• Mathematical model of NF-\( \kappa\)B regulatory module
• A minimal spatio-temporal model of the NF-\(\kappa \)B signalling pathway exhibits a range of behaviours
• Mathematical modeling of preadipocyte fate determination
• NF-\( \kappa\)B spiky oscillations
• Algorithmic asymptotic analysis of the NF-\(\kappa\mathrm B\) signaling system
• Critical roles of I\(\kappa\)B\(\alpha\) and RelA phosphorylation in transitional oscillation in NF-\(\kappa\)B signaling module

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