A systematic survey of the response of a model NF-B signalling pathway to TNF stimulation

DOI10.1016/J.JTBI.2011.12.014MaRDI QIDQ285222zbMATH OpenOpenAlexWikidataFDO

Authors Yunjiao Wang, Pawel Paszek, Caroline A. Horton, Hong Yue, Michael R. H. White, Douglas B. Kell, Mark R. Muldoon, David S. Broomhead

Publication date 19 May 2016

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1016/j.jtbi.2011.12.014

zbMATH Keywords

oscillationsbifurcation analysisNF-\(\kappa\)B signalling pathwayparameter sensitivity

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Cell biology (92C37)

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Cites work

• Mathematical model of NF-\( \kappa\)B regulatory module
• Simulating, Analyzing, and Animating Dynamical Systems

Cited in

(13)

• \textit{NF}-\(\kappa B\) oscillations and cell-to-cell variability
• A method of `speed coefficients' for biochemical model reduction applied to the NF-\(\kappa\)B system
• Analysis of Fn14-NF-\(\kappa\)B signaling response dynamics using a mechanistic model
• Mathematical simulation of linear ubiquitination in T cell receptor-mediated NF-\(\kappa \mathrm{B}\) activation pathway
• Global uncertainty analysis for a model of TNF-induced NF-\(\kappa\)B signalling
• Spatio-temporal modelling of the NF-\(\kappa\)B intracellular signalling pathway: the roles of diffusion, active transport, and cell geometry
• Critical roles of I\(\kappa\)B\(\alpha\) and RelA phosphorylation in transitional oscillation in NF-\(\kappa\)B signaling module
• A simple model of NF-\(\kappa\)B dynamics reproduces experimental observations
• scientific article; zbMATH DE number 1950563 (Why is no real title available?)
• Mathematical models for immunology: current state of the art and future research directions
• Receptor-dependent sensitivity of NF-\(\kappa\)B to low physiological level
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• Algorithmic asymptotic analysis of the NF-\(\kappa\mathrm B\) signaling system

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Uses Software

• AUTO2000
• XPPAUT

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